AMMONIUM ETHANOATE

Ammonium ethanoate is a chemical compound with the formula NH4CH3CO2. 

Ammonium ethanoate is a white, hygroscopic solid and can be derived from the reaction of ammonia and acetic acid. 

Ammonium ethanoate is widely used in the chemical analysis, in the pharmaceutical industry, the food sector in preserving foods, and in various other industries too. 

CAS Number: 631-61-8

EC Number: 211-162-9

Chemical Formula: C2H7NO2

Molar Mass: 77.083 g·mol−1

Synonyms: AMMONIUM ACETATE, 631-61-8, Acetic acid, ammonium salt, Azanium Acetate, acetic acid ammonium salt, ammoniumacetate, azanium;acetate, ammonium ethanoate, AcONH4, Ammonium acetate-D3, CH3COONH4, CH3CO2NH4, UNII-RRE756S6Q2, HSDB 556, RRE756S6Q2, NH4OAc, AMMONIUM ACETICUM, EINECS 211-162-9, AI3-26540, INS No. 264, DTXSID5023873, CHEBI:62947, EC 211-162-9, ammonia acetate, MFCD00013066, E264, E 264, E-264, AMMONIUM ACETATE (II), AMMONIUM ACETATE [II], AMMONIUM ACETATE (MART.), AMMONIUM ACETATE [MART.], amoniumacetate, ammonium-acetate, acetic acid amine, ammonium acetate-, ammonia acetate salt, Ammonium Acetate ACS, AAT (CHRIS Code), AMMONIUM ACETATE [MI], Ammonium acetate solution, 5M, C2H4O2.H3N, DTXCID203873, AMMONIUM ACETATE [HSDB], AMMONIUM ACETATE [INCI], AMMONIUM ACETICUM [HPUS], AMMONIUM ACETATE [WHO-DD], USFZMSVCRYTOJT-UHFFFAOYSA-N, Acetic acid ammonium salt (1:1), Ammonium acetate, biochemical grade, C2-H4-O2.H3-N, Acetic acid, ammonium salt (1:1), NA9079, AKOS015904610, FT-0622306, EN300-31599, 211-162-9 [EINECS], 631-61-8 [RN], Acétate d’ammonium [French] [ACD/IUPAC Name], Acetic acid, ammonium salt [ACD/Index Name], Ammonium acetate [ACD/IUPAC Name] [Wiki], ammonium ethanoate, Ammoniumacetat [German] [ACD/IUPAC Name], MFCD00013066 [MDL number], NH4OAc [Formula], 211-162-9MFCD00013066, acetic acid amine, acetic acid ammoniate, AcONH4, ammonia acetate, Ammonium acetatemissing, ammoniumacetate, azanium acetate, azanium and acetate, azanium ethanoate, buffers, E 264, E264, E-264, INS No. 264, OmniPur Ammonium Acetate – CAS 631-61-8 – Calbiochem, OmniPur(R) Ammonium Acetate

Ammonium ethanoate appears as a white crystalline solid. 

The primary hazard is the threat to the environment. 

Immediate steps should be taken to limit Ammonium ethanoate spread to the environment. 

Ammonium ethanoate is used in chemical analysis, in pharmaceuticals, in preserving foods, and for other uses.

Ammonium ethanoate is an ammonium salt obtained by reaction of ammonia with acetic acid. 

A deliquescent white crystalline solid, Ammonium ethanoate has a relatively low melting point (114℃) for a salt. 

Ammonium ethanoate is used as a food acidity regulator, although no longer approved for this purpose in the EU. 

Ammonium ethanoate has a role as a food acidity regulator and a buffer. 

Ammonium ethanoate is an acetate salt and an ammonium salt.

Ammonium ethanoate is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 to < 10 000 tonnes per annum. Ammonium ethanoate is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing. Ammonium ethanoate, also known as spirit of Mindererus in aqueous solution, is a chemical compound with the formula NH4CH3CO2.  Ammonium ethanoate is a white, hygroscopic solid and can be derived from the reaction of ammonia and acetic acid.  Ammonium ethanoate is available commercially. Ammonium ethanoate is a white crystalline solid formed when ammonia reacts with acetic acid.  Ammonium ethanoate is widely used in the chemical analysis, in the pharmaceutical industry, the food sector in preserving foods, and in various other industries too.  Ammonium ethanoate is also used as a buffer in topical personal care and cosmetic products in manufacturing skin lotions, shampoos, conditioners and more. Ammonium ethanoate or C2H7NO2 appears in the form of a crystalline white solid with a slight acetous odour.  This ammonium salt is derived from the reaction of ammonia and acetic acid.  The chemical name of this salt is Ammonium ethanoate while it is even known as the spirit of Mindererus on the aqueous form.  The other names of Ammonium ethanoate include Spirit of Mindererus and Azanium Acetate.  Ammonium ethanoate is extensively used in the preservation of foods; in pharmaceuticals and the chemical analysis procedure.  Ammonium ethanoate works most effectively when used in the form of a food acidity regulator.  However, Ammonium ethanoate is one of the major threats to the atmosphere or the living environment.  Instant measures need to be taken to restricting the spread of this hazardous sale in the environment. Ammonium ethanoate is widely utilized as a catalyst in the Knoevenagel condensation.  Ammonium ethanoate is the primary source of ammonia in the Borch reaction in organic synthesis.  Ammonium ethanoate is used with distilled water to make a protein precipitating reagent.  Ammonium ethanoate acts as a buffer for electrospray ionization (ESI) mass spectrometry of proteins and other molecules and as mobile phases for high performance liquid chromatography (HPLC).  Sometimes, Ammonium ethanoate is used as a biodegradable de-icing agent and an acidity regulator in food additives. Ammonium ethanoate is a salt that has interesting chemical properties and due to this reason, the pharmaceutical industry uses Ammonium ethanoate as an intermediary and raw material in various processes.  Ammonium ethanoate is a salt that forms from the reaction of ammonia and acetic acid.  Also, Ammonium ethanoate is useful for applications that require buffer solutions.  The Henry reactions are the most common reactions that use Ammonium ethanoate.  In an aqueous solution, Ammonium ethanoate is a chemical compound that we know by the name spirit of Mindererus or Ammonium ethanoate, which is a white, hygroscopic solid we can derive from the reaction of ammonia and acetic acid. Ammonium ethanoate has a variety of applications in molecular biology and chromatography.  Ammonium ethanoate is a useful reagent for the purification and precipitation of DNA and protein.  Ammonium ethanoate can be used in the HPLC and MS analysis of peptides, oligosaccharides, and proteins. Uses of Ammonium ethanoate: Ammonium ethanoate is used in explosives, foam rubbers, vinyl plastics, and drugs. Ammonium ethanoate is also used for preserving meats, dyeing and stripping, determining lead and iron, and separating lead sulfate from other sulfates. There are large scale uses of Ammonium ethanoate. Ammonium ethanoate is used in the form of a food acidity regulator.  Ammonium ethanoate is the food additive used for changing or controlling the alkalinity or acidity of foods.  Ammonium ethanoate is also widely used in the form of a catalyst in the Knoevenagel condensation procedure.  Ammonium ethanoate serves as one of the best sources of ammonia is the Borch reaction during organic synthesis.  Ammonium ethanoate is used in combination with wholly distilled water for making a kind of protein precipitating reagent.  Ammonium ethanoate even serves in the form of a buffer for ESI or electrospray ionization mass spectrometry of molecules and proteins and the form of a mobile phase for HPLC or high-performance liquid chromatography.  Quite rarely though, Ammonium ethanoate is even used in the form of a biodegradable de-icing agent.  Ammonium ethanoate even works best when used as a diuretic. Ammonium ethanoate tends to be unstable at low pressure, and this is why Ammonium ethanoate is used for substituting cell buffers with different non-explosive salts in the preparation of mass spectrometry samples.  Other important uses of Ammonium ethanoate include: Ammonium ethanoate is used in the manufacture of explosives. Ammonium ethanoate is used for making foam rubber. Ammonium ethanoate is used for preserving meat.Used for manufacturing vinyl plastics. Ammonium ethanoate is used in different agricultural products. In analytical chemistry, Ammonium ethanoate is used in the form of a reagent.  Ammonium ethanoate is used as a reagent in different dialysis procedures for the elimination of contaminants through diffusion. In agricultural chemistry, Ammonium ethanoate, when used as a reagent, helps in determining soil CEC or cation exchange capacity along with the availability of potassium in the soil.  Ammonium ethanoate is the main precursor to acetamide: NH4CH3CO2 → CH3C(O)NH2 + H2O Ammonium ethanoate is also used as a diuretic. Buffer: As the salt of a weak acid and a weak base, Ammonium ethanoate is often used with acetic acid to create a buffer solution.  Ammonium ethanoate is volatile at low pressures.  Because of this, Ammonium ethanoate has been used to replace cell buffers that contain non-volatile salts in preparing samples for mass spectrometry. Ammonium ethanoate is also popular as a buffer for mobile phases for HPLC with ELSD detection for this reason.  Other volatile salts that have been used for this include ammonium formate. When dissolving Ammonium ethanoate in pure water, the resulting solution typically has a pH of 7, because the equal amounts of acetate and ammonium neutralize each other.  However, Ammonium ethanoate is a dual component buffer system, which buffers around pH 4.75 ± 1 (acetate) and pH 9.25 ± 1 (ammonium), but Ammonium ethanoate has no significant buffer capacity at pH 7, contrary to common misconception. Other: Ammonium ethanoate is a biodegradable de-icing agent. Ammonium ethanoate is a catalyst in the Knoevenagel condensation and as a source of ammonia in the Borch reaction in organic synthesis. Ammonium ethanoate is a protein precipitating reagent in dialysis to remove contaminants via diffusion. Ammonium ethanoate is a reagent in agricultural chemistry for determination of soil CEC (cation exchange capacity) and determination of available potassium in soil wherein the ammonium ion acts as a replacement cation for potassium. Ammonium ethanoate is part of Calley's method for lead artifact conservation Food additive: Ammonium ethanoate is also used as a food additive as an acidity regulator; INS number 264.  Ammonium ethanoate  is approved for usage in Australia and New Zealand. Widespread uses by professional workers: Ammonium ethanoate is used in the following products: pH regulators and water treatment products, laboratory chemicals and fertilisers. Ammonium ethanoate is used in the following areas: health services, scientific research and development, agriculture, forestry and fishing and building & construction work. Ammonium ethanoate is used for the manufacture of: food products and textile, leather or fur. Release to the environment of Ammonium ethanoate can occur from industrial use: formulation of mixtures and formulation in materials. Other release to the environment of Ammonium ethanoate is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use as processing aid, indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment) and indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints). Uses at industrial sites: Ammonium ethanoate is used in the following products: pH regulators and water treatment products, laboratory chemicals, leather treatment products and textile treatment products and dyes. Ammonium ethanoate is used in the following areas: health services, scientific research and development and building & construction work. Ammonium ethanoate is used for the manufacture of: chemicals, textile, leather or fur, food products and fabricated metal products. Release to the environment of Ammonium ethanoate can occur from industrial use: in processing aids at industrial sites, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid and in the production of articles. Industry Uses: Agricultural chemicals (non-pesticidal) Catalyst Intermediates Not Known or Reasonably Ascertainable Other (specify) Solids separation (precipitating) agent, not otherwise specified pH regulating agent Consumer Uses: Ammonium ethanoate is used in the following products: perfumes and fragrances and cosmetics and personal care products. Other release to the environment of Ammonium ethanoate is likely to occur from: indoor use as processing aid. Other Consumer Uses: Agricultural chemicals (non-pesticidal) Other (specify) Photosensitive chemicals Applications of Ammonium ethanoate: Ammonium ethanoate is widely utilized as a catalyst in the Knoevenagel condensation.  Ammonium ethanoate is the primary source of ammonia in the Borch reaction in organic synthesis.  Ammonium ethanoate is used with distilled water to make a protein precipitating reagent.  Ammonium ethanoate acts as a buffer for electrospray ionization (ESI) mass spectrometry of proteins and other molecules and as mobile phases for high performance liquid chromatography (HPLC).  Sometimes, Ammonium ethanoate is used as a biodegradable de-icing agent and an acidity regulator in food additives. Structural Formula of Ammonium ethanoate: As Ammonium ethanoate salt is constituted of a weak acid and a weak base and is often used with acetic acid to create a buffer solution.  Ammonium ethanoate chemical component is volatile at low pressures because Ammonium ethanoate has been used to replace cell buffers with non-volatile salts in preparing the chemical samples. Production of Ammonium ethanoate: Ammonium ethanoate is produced by the neutralization of acetic acid with ammonium carbonate or by saturating glacial acetic acid with ammonia. Obtaining crystalline Ammonium ethanoate is difficult on account of Ammonium ethanoate hygroscopic nature. Two methods can be used for obtaining Ammonium ethanoate, and they are: Through the saturation of glacial acetic acid or CH3COOH with NH3 or ammonia. Through the neutralization of acetic acid with (NH4)2CO3 or ammonium carbonate. These are the two basic methods used for obtaining Ammonium ethanoate, though some new methods have also surfaced in recent years. Ammonium ethanoate functions in the form of an acetamide precursor.  This results in a reaction that follows like this: NH4CH3CO2 → CH3C (O) NH2 + H2O General Manufacturing Information of Ammonium ethanoate: Industry Processing Sectors: Agriculture, Forestry, Fishing and Hunting All Other Basic Inorganic Chemical Manufacturing All Other Chemical Product and Preparation Manufacturing Pharmaceutical and Medicine Manufacturing Occurrence of Ammonium ethanoate: In nature, Ammonium ethanoate is not present in a free compound state.  But, ammonium and acetate ions are present in many biochemical processes. Properties of Ammonium ethanoate: Physical Properties: Ammonium ethanoate is a hygroscopic white solid with a slightly acidic odor.  Furthermore, Ammonium ethanoate melting point is 113oC.  Also, Ammonium ethanoate is highly soluble in water and Ammonium ethanoate density in this liquid is 1.17 g/mL-1. Chemical Properties: Ammonium ethanoate is a slat of a weak acid (acetic acid) and a weak base (ammonia).  Use this salt with acetic acid to prepare a buffer solution that will regulate Ammonium ethanoate pH. Nevertheless, Ammonium ethanoate use as a buffering agent is not very extensive because Ammonium ethanoate can be volatile in low pressures. History of Ammonium ethanoate: The synonym Spirit of Mindererus is named after R. Minderer, a physician from Augsburg. Handling and storage of Ammonium ethanoate: Precautions for safe handling: Provide adequate ventilation.  When not in use, keep containers tightly closed. Advice on general occupational hygiene: Keep away from food, drink and animal feedingstuffs. Conditions for safe storage, including any incompatibilities: Store in a dry place.  Keep container tightly closed.  Hygroscopic solid. Incompatible substances or mixtures: Observe hints for combined storage. Protect against external exposure, such as: humidity Consideration of other advice: Specific designs for storage rooms or vessels Recommended storage temperature: 15–25 °C Specific end use(s): No information available. Stability and Reactivity of Ammonium ethanoate: Reactivity: Ammonium ethanoate is not reactive under normal ambient conditions. Chemical stability: Moisture-sensitive.  Hygroscopic solid. Possibility of hazardous reactions: Violent reaction with: Strong oxidiser, Hypochlorites, Gold compound. Conditions to avoid: Protect from moisture. Incompatible materials: There is no additional information. First Aid Measures of Ammonium ethanoate: INHALATION: Remove victim to fresh air; rinse nose and mouth with water.  If not breathing, give artificial respiration.  If breathing is difficult, give oxygen. INGESTION: Induce vomiting immediately. Give large amounts of water. EYES: Flush with water for at least 15 min. SKIN: Flush with soap and water. General notes: Take off contaminated clothing. Following inhalation: Provide fresh air.  In all cases of doubt, or when symptoms persist, seek medical advice. Following skin contact: Rinse skin with water/shower. Following eye contact: Rinse cautiously with water for several minutes.  In all cases of doubt, or when symptoms persist, seek medical advice. Following ingestion: Rinse mouth.  Call a doctor if you feel unwell. Most important symptoms and effects, both acute and delayed: Nausea, Vomiting, Spasms, Circulatory collapse. Indication of any immediate medical attention and special treatment needed: none. Firefighting measures of Ammonium ethanoate: Suitable extinguishing media: co-ordinate firefighting measures to the fire surroundings water, foam, alcohol resistant foam, dry extinguishing powder, ABC-powder. Unsuitable extinguishing media: water jet Special hazards arising from Ammonium ethanoate or mixture: None. Hazardous combustion products: In case of fire may be liberated:  Nitrogen oxides (NOx), Carbon monoxide (CO), Carbon dioxide (CO₂) Advice for firefighters: In case of fire and/or explosion do not breathe fumes.  Fight fire with normal precautions from a reasonable distance.  Wear self-contained breathing apparatus. Accidental Release Measures of Ammonium ethanoate: Personal precautions, protective equipment and emergency procedures: For non-emergency personnel: No special measures are necessary. Environmental precautions: Keep away from drains, surface and ground water. Methods and material for containment and cleaning up: Advice on how to contain a spill: Covering of drains.  Take up mechanically. Advice on how to clean up a spill: Take up mechanically. Other information relating to spills and releases: Place in appropriate containers for disposal.  Ventilate affected area. Preventive Measures of Ammonium ethanoate: The scientific literature for the use of contact lenses in industry is conflicting.  The benefit or detrimental effects of wearing contact lenses depend not only upon Ammonium ethanoate, but also on factors including the form of Ammonium ethanoate, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses.  However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye.  In those specific cases, contact lenses should not be worn.  In any event, the usual eye protection equipment should be worn even when contact lenses are in place. Identifiers of Ammonium ethanoate: CAS Number: 631-61-8 ChEBI: CHEBI:62947 ChemSpider: 11925 ECHA InfoCard: 100.010.149 EC Number: 211-162-9 PubChem CID: 517165 RTECS number: AF3675000 UNII: RRE756S6Q2 UN number: 3077 CompTox Dashboard (EPA): DTXSID5023873 InChI: InChI=1S/C2H4O2.H3N/c1-2(3)4;/h1H3,(H,3,4);1H3 Key: USFZMSVCRYTOJT-UHFFFAOYSA-N InChI=1/C2H4O2.H3N/c1-2(3)4;/h1H3,(H,3,4);1H3 Key: USFZMSVCRYTOJT-UHFFFAOYAY SMILES: O=C([O-])C.[N+H4] Synonyms: Ammonium ethanoate Linear Formula: CH3CO2NH4 CAS Number: 631-61-8 Molecular Weight: 77.08 EC Number: 211-162-9 CAS number: 631-61-8 EC number: 211-162-9 Grade: ACS,Reag. Ph Eur Hill Formula: C₂H₇NO₂ Chemical formula: CH₃COONH₄ Molar Mass: 77.08 g/mol HS Code: 2915 29 00 Properties of Ammonium ethanoate: Chemical formula: C2H7NO2 Molar mass: 77.083 g·mol−1 Appearance: White solid crystals, deliquescent Odor: Slightly acetic acid like Density: 1.17 g/cm3 (20 °C) 1.073 g/cm3 (25 °C) Melting point: 113 °C (235 °F; 386 K) Solubility in water: 102 g/100 mL (0 °C) 148 g/100 mL (4 °C) 143 g/100 mL (20 °C) 533 g/100 mL (80 °C) Solubility: Soluble in alcohol, SO2, acetone, liquid ammonia Solubility in methanol: 7.89 g/100 mL (15 °C) 131.24 g/100 g (94.2 °C) Solubility in dimethylformamide: 0.1 g/100 g Acidity (pKa): 9.9 Basicity (pKb): 33 Magnetic susceptibility (χ): -41.1·10−6 cm3/mol Viscosity: 21 Density: 1.17 g/cm3 (20 °C) Melting Point: 114 °C pH value: 6.7 - 7.3 (50 g/l, H₂O, 25 °C) Vapor pressure: <0.001 hPa Bulk density: 410 kg/m3 Solubility: 1480 g/l Color: Colorless Density: 1.170 g/cm3 (20 °C) Form: Solid Grade: Reagent Grade Incompatible Materials: Strong oxidizing agents, Strong acids Melting Point/Range: 113 °C Purity Percentage: 99.99 Purity Details: ≥99.99% Solubility in Water: 1.480 g/l (20 °C) pH-Value: 6.7-7.3 (20 °C) Storage Temperature: Ambient Molecular Weight: 77.08 g/mol Hydrogen Bond Donor Count: 1 Hydrogen Bond Acceptor Count: 2 Rotatable Bond Count: 0 Exact Mass: 77.047678466 g/mol Monoisotopic Mass: 77.047678466 g/mol Topological Polar Surface Area: 41.1Ų Heavy Atom Count: 5 Complexity: 25.5 Isotope Atom Count: 0 Defined Atom Stereocenter Count: 0 Undefined Atom Stereocenter Count: 0 Defined Bond Stereocenter Count: 0 Undefined Bond Stereocenter Count: 0 Covalently-Bonded Unit Count: 2 Compound Is Canonicalized: Yes Specifications of Ammonium ethanoate: Assay (acidimetric): ≥ 98.0 % Insoluble matter: ≤ 0.005 % pH-value (5 %; water, 25 °C): 6.7 - 7.3 Chloride (Cl): ≤ 0.0005 % Nitrate (NO₃): ≤ 0.001 % Sulfate (SO₄): ≤ 0.001 % Heavy metals (as Pb): ≤ 0.0002 % Ca (Calcium): ≤ 0.001 % Fe (Iron): ≤ 0.0002 % Substances reducing potassium permanganate (as formic acid): ≤ 0.005 % Residue on ignition (as sulfate): ≤ 0.01 % Water: ≤ 2.0 % Appearance of Ammonium ethanoate: complying Identity (IR): complying Assay: Min. 97.0 % pH (5 %, 25 °C): 6.7 - 7.3 Sulfated ash: Max. 0.01 % Water insoluble matter: Max. 0.005 % Metal trace analysis (ICP): Max. 100 ppm Iron (Fe): Max. 5 ppm Heavy metals (as Pb): Max. 5 ppm Chloride (Cl): Max. 5 ppm Nitrate (NO3): Max. 0.001 % Sulfate (SO4): Max. 0.001 % Structure of Ammonium ethanoate: Crystal structure: Orthorhombic Thermochemistry of Ammonium ethanoate: Std enthalpy of formation (ΔfH⦵298): −615 kJ/mol[2] Related Products of Ammonium ethanoate: Diphenyltin Dichloride Dipotassium Hydrogen Phosphite 1,​1'-​Diisooctyl Ester 2,​2'-​[(Dioctylstannylene)​bis(thio)​]​bis-acetic Acid (Technical Grade) Diphenylsilane-D2 4-ethynyl-α,α-diphenyl-Benzenemethanol Names of Ammonium ethanoate: Regulatory process names: Ammonium acetate Ammonium acetate ammonium acetate IUPAC names: acetic acid ammonium salt Acetic acid, ammonium salt Acetic Acid, Ammonium Salt, Ammonium ethanoate Acetic acid; azane acetic acid; azane AMMONIUM ACETATE Ammonium Acetate Ammonium acetate ammonium acetate Ammonium Acetate Ammonium acetate Ammonium ethanoate azanium acetate azanium;acetate Trade names: AMMONIUM ACETATE Ammonium Acetate Other identifiers: 1066-32-6 631-61-8 8013-61-4 856326-79-9 858824-31-4 92206-38-7