BHT (Butylated hydroxytoluene)
BHT (Butylated hydroxytoluene)
DESCRIPTION
ANTIOXIDANT BHT
CAS 000128-37-0
Butylhydroxytoluene
Product description
CAS No.: 128-37-0
Primarily acts as an antioxidant food additive because of its ability to preserve fats.
In cosmetics, it’s also used as a preservative. As an antioxidant, it helps fight against the deterioration of cosmetic products caused by chemical reactions with oxygen.
It’s also known to work synergistically with other antioxidants.
Synonyms: 2,6-Di-tert-butyl-4-methylphenol 2,6-Di-tert-butyl-p-cresol (DBPC), Additin RC 7110 , Dibutylated hydroxytoluene, 4-Methyl-2,6-di-tert-butyl phenol
Butyhlhydroxytoluene (BHT) is mainly used as a food preservativeand serves as an antioxidant. Also it appears as an ingredient in household products, personal care products and
pesticides.
Synonyms : Vulkanox BHT, BHT, Agidol-1, lonol, Lowinox BHT, 2,6-di-tert-butyl-4-methylphenol, Vanlube PCX, Butylhydroxytoluene, CAO-3 Antioxidant, Dibunol, Naugard BHT.
International name : BHT
Chemical formula : C 15 H 24 O
Release form and appearance : white crystalline powder or flakes
Butylated hydroxytoluene (BHT), also known as dibutylhydroxytoluene, is a lipophilic organic compound, chemically a derivative of phenol, that is useful for its antioxidant properties.
BHT is widely used to prevent free radical-mediated oxidation in fluids (e.g. fuels, oils) and other materials, and the regulations overseen by the U.S. F.D.A.—which considers BHT
to be “generally recognized as safe”—allow small amounts to be added to foods. Despite this, and the earlier determination by the National Cancer Institute that BHT was noncarcinogenic
in an animal model, societal concerns over its broad use have been expressed. BHT has also been postulated as an antiviral drug, but as of March 2020, use of BHT as a drug is not
supported by the scientific literature and it has not been approved by any drug regulatory agency for use as an antiviral.
Application : Antioxidant BHT has high antioxidant properties, effectively improving the stability of oils, preventing sludge formation. In addition to its use in motor and industrial oils,
the BHT antioxidant finds its application in the production of fluids for metalworking, cosmetics, pharmaceuticals, embalming fluids, antifreeze, antifreeze and auto chemistry. In the
petroleum industry, where BHT is known as a fuel additive, it is used in hydraulic fluids, turbine and transmission oils, and jet fuels.
Applications
BHT is listed under several categories in catalogues and databases, such as food additive, household product ingredient, industrial additive, personal care product/cosmetic ingredient,
pesticide ingredient, plastic/rubber ingredient and medical/veterinary/research.
Food additive
BHT is primarily used as an antioxidant food additive.In the United States, it is classified as generally recognized as safe (GRAS) based on a National Cancer Institute study from
1979 in rats and mice. It is approved for use in the U.S. by the Food and Drug Administration: For example, 21 CFR § 137.350(a)(4) allows BHT up to 0.0033% by weight in “enriched rice”,
while 9 CFR § 381.147](f)(1) allows up to 0.01% in poultry “by fat content”. It is permitted in the European Union under E321.
BHT is used as a preservative ingredient in some foods. With this usage BHT maintains freshness or prevents spoilage; it may be used to decrease the rate at which the texture, color,
or flavor of food changes.
Some food companies have voluntarily eliminated BHT from their products or have announced that they were going to phase it out.
Antioxidant
BHT is also used as an antioxidant in products such as metalworking fluids, cosmetics, pharmaceuticals, rubber, transformer oils, and embalming fluid.[citation needed] In the petroleum
industry, where BHT is known as the fuel additive AO-29, it is used in hydraulic fluids, turbine and gear oils, and jet fuels. BHT is also used to prevent peroxide formation in organic
ethers and other solvents and laboratory chemicals. It is added to certain monomers as a polymerisation inhibitor to facilitate their safe storage. Some additive products contain
BHT as their primary ingredient, while others contain the chemical merely as a component of their formulation, sometimes alongside butylated hydroxyanisole (BHA).
Health effects
Like many closely related phenol antioxidants, BHT has low acute toxicity (e.g., the desmethyl analog of BHT, 2,6-di-tert-butylphenol, has an LD50 of >9 g/kg).The US Food and Drug
Administration classifies BHT as generally recognized as safe (GRAS) as a food preservative when used according in an approved manner. In 1979, the National Cancer Institute determined
that BHT was noncarcinogenic in a mouse model.
Based on various, disparate primary research reports, BHT has been suggested to have anti-viral activity, and the reports divide into various study types. First, there are studies that
describe virus inactivation—where treatment with the chemical results in disrupted or otherwise inactivated virus particles. The action of BHT in
these is akin to the action of many other organic compounds, e.g., quaternary ammonium compounds, phenolics, and detergents, which disrupt viruses by insertion of the chemical into
the virus membrane, coat, or other structure,which are established methods of viral disinfection secondary to methods of chemical oxidation and UV irradiation. In addition,
there is a report of BHT use, topically against genital herpes lesions, a report of inhibitory activity in vitro against pseudorabies (in cell culture),
and two studies, in veterinary contexts, of use of BHT to attempt to protect against virus exposure (pseudorabies in mouse and swine, and Newcastle in chickens). The relevance of other
reports, regarding influenza in mice, is not easily discerned.Notably, this series of primary research reports does not support a general conclusion of independent confirmation of the
original research results, nor are there critical reviews appearing thereafter, in secondary sources, for the various host-virus systems studied with BHT.
Hence, at present, the results do not present a scientific consensus in favour of the conclusion of the general antiviral potential of BHT when dosed in humans. Moreover, as of March
2020, no guidance from any of the internationally recognized associations of infectious disease specialists had advocated use of BHT products as an antiviral therapy or prophylactic
2,6-di-tert-Butyl-4-methylphenol
EU. Food Contact Regenerated Cellulose Directive – Authorised Substances
2,6-di-tert-butyl-p-cresol
Butylated hydroxytoluene
CAS names
Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl-
IUPAC names
– 2,6-ditert-butyl-4-methylphenol
2,6 di-tert-butyl-p-cresol
2,6-(Di-t-butyl)-p-cresol
2,6-BIS(1,1-DIMETHYLETHYL)-4-METHYLPHENOL
2,6-di-t-Butyl-p-cresol
2,6-Di-tert-buthyl-4-methyphenol
2,6-di-tert-butil-para-cresol
2,6-Di-tert-butyl-4-hydroxytoluene
2,6-Di-tert-butyl-4-methyl-1-hydroxybenzene
2,6-di-tert-butyl-4-methylphenol;
2,6-DI-TERT-BUTYL-P-CRESOL(30435)
2,6-Di-tert-butyl-p-cresol, BHT, Butylated hydroxytoluene, Butylhydroxytoluene, DBPC, Butylhydroxytoluenum
2,6-di-tert-butyl-p-cresol; BHT
2,6-di-tert-butyl-p-crezol
2,6-Di-tert-butyl-p-kresol
2,6-di-tert-butyl-p-krezol
2,6-di-tert-buytl-p-cresol
2,6-di-tert.-butyl-4-methylphenol
2,6-di-terz-butil-4-metilfenolo
2,6-ditert-butyl-4-methylphenol
2,6-ditert-butyl-4-methylphenol.
4-methyl-2,6-di-(terc) butylfenol
4-methyl-2,6-di-tert-butyl-phenol
BHT
Butil-hidroxi-toluol
butylated hydroxytoluene, BHT
Butylhydroxytoluol (BHT)
Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl
PHENOL,2,6-BIS(1,1-DIMETHYLETHYL)-4-METHYL-
4-HYDROXY-3,5-DI-TERT-BUTYLTOLUENE
4-methyl-2,6-di-tert-butylphenol antioxidant premix (BHT) of technical grade
Agidol 1
BHT of technical grade antioxidant premix, of A and B types
BUTYLATED HYDROXY TOLUENE
P-CRESOL, 2,6-DI-TERT-BUTYL-
102962-45-8
CAS number
128-37-0
CAS number
1394965-02-6
Other
CAS number
1456709-94-6
CAS number
2055662-96-7
CAS number
259752-53-9
CAS number
290348-23-1
CAS number
338986-13-3
CAS number
36631-28-4
CAS number
42615-30-5
CAS number
50356-19-9
CAS number
50641-99-1
CAS number
52683-46-2
CAS number
53571-70-3
CAS number
58500-82-6
CAS number
83047-16-9
Other
CAS number
97123-41-6
CAS number
Butylhydroxytoluene
E 321
Synonym: Butylhydroxytoluene
CAS Number 128-37-0 Empirical Formula (Hill Notation) C15H24O Molecular Weight 220.35 MDL number MFCD00011644 E Number E321 EC Index Number 204-881-4
2,6-Di-tert-butyl-4-methylphenol
128-37-0
Butylated hydroxytoluene
Butylhydroxytoluene
2,6-Di-tert-butyl-p-cresol
2,6-Di-t-butyl-4-methylphenol
Ionol
DBPC
BHT
Dibunol
Stavox
Ionol CP
Impruvol
Topanol
Dalpac
Deenax
Ionole
Vianol
Antioxidant KB
3,5-Di-tert-butyl-4-hydroxytoluene
2,6-ditert-butyl-4-methylphenol
Antioxidant 4K
Sumilizer BHT
Topanol O
Topanol OC
Vanlube PC
Antioxidant DBPC
Sustane BHT
Tenamene 3
Vanlube PCX
Antioxidant 29
Antioxidant 30
Nonox TBC
Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl-
Tenox BHT
Chemanox 11
Ionol 1
Agidol
Catalin CAO-3
Advastab 401
Ionol (antioxidant)
BUKS
Parabar 441
Paranox 441
2,6-Di-tert-butyl-4-cresol
Catalin antioxydant 1
Antrancine 8
Butylated hydroxytoluol
Vulkanox KB
Di-tert-butyl-p-cresol
Dibutylated hydroxytoluene
Kerabit
Tonarol
Ional
2,6-Bis(1,1-dimethylethyl)-4-methylphenol
AO 4K
CAO 1
CAO 3
Di-tert-butyl-p-methylphenol
Antioxidant MPJ
Antioxidant 4
Toxolan P
Alkofen BP
o-Di-tert-butyl-p-methylphenol
Swanox BHT
Tenamen 3
Antox QT
Antioxidant 264
4-Methyl-2,6-tert-butylphenol
Agidol 1
Bht (food grade)
2,6-Di-tert-butyl-1-hydroxy-4-methylbenzene
2,6-Di-tert-butyl-p-methylphenol
AO 29
NCI-C03598
2,6-DI-T-BUTYL-P-CRESOL
4-Methyl-2,6-di-tert-butylphenol
Butyl hydroxy toluene
Antioxidant T 501
Nocrac 200
2,6-Di-terc.butyl-p-kresol
4-Hydroxy-3,5-di-tert-butyltoluene
Caswell No. 291A
FEMA No. 2184
Dbpc (technical grade)
P 21
Annulex BHT
AOX 4K
Bht(food grade)
4-Methyl-2,6-di-terc. butylfenol
AOX 4
1-Hydroxy-4-methyl-2,6-di-tert-butylbenzene
Di-tert-butylcresol
Dibutylhydroxytoluene
Butylohydroksytoluenu [Polish]
Butylated hydroxytoluene (bht)
Di-tert-butyl-p-cresol (VAN)
Dbpc(technical grade)
E321
HSDB 1147
p-Cresol, 2,6-di-tert-butyl-
BHT 264
2,6-ditert-butyl-4-methyl-phenol
NSC 6347
2,6-Di-tert-butyl-4-methyl-phenol
EINECS 204-881-4
2,6-Di-tert-butyl-4-hydroxytoluene
CHEMBL146
2,6-Di-terc.butyl-p-kresol [Czech]
EPA Pesticide Chemical Code 022105
2,6-Di-tert-butyl-4-methylhydroxybenzene
4-Methyl-2,6-di-terc. butylfenol [Czech]
4-Methyl-2,6-di-t-butyl-phenol
NSC-6347
2,6-di-tert-butyl-4-methyl phenol
2,6-bis(tert-butyl)-4-methylphenol
950-56-1
NCGC00091761-03
2,6-Di-tert-butyl-4-methylphenol, 99%
CAS-128-37-0
Butylohydroksytoluenu
Ionol CP-antioxidant
1,3-Dioxolane, 99.5+%, pure, stabilized
2,6-Di-tert-butyl-4-methylphenol, 99.8%
Ionol” CP-antioxidant
Dibutylcresol
Popol
4-Methyl-2,6-ditertbutylphenol
Antracine 8
Embanox BHT
Hydagen DEO
Lowinox BHT
Nipanox BHT
1,3-Dioxolane, 99.8%, anhydrous, stabilized with 75 ppm BHT, AcroSeal(R)
BHT Swanox
BHT, food grade
Butylhydroxytoluenum
Ionol BHT
Ralox BHT
2, food grade
Butylated hydroxytoluene [BAN:NF]
Dibutyl-para-cresol
Topanol OC and 0
Butylated hydroxytoluene [USAN:BAN]
PubChem20842
Spectrum_001790
ACMC-1BUTL
Butylated Hydroxytoluol;
SpecPlus_000768
Methyldi-tert-butylphenol
Hydagen DEO (Salt/Mix)
EC 204-881-4
2,6-di-Butyl-para-cresol
2.6-di-t-butyl-p-cresol
SCHEMBL3950
2,6-ditert-butyl-p-cresol
p-Cresol,6-di-tert-butyl-
Di-tert-Butylparamethylphenol
2,6-di-tert.butyl-p-cresol
Di-tert-Butyl-4-methylphenol
Butylated hydroxytoluene (NF)
2,6-bis-tert-butyl-p-cresol
2,6-di-tert-butyl-paracresol
BHT (butylated hydroxytoluene)
2,6-di-tert. butyl-p-cresol
2,6-di-tert.-butyl-p-cresol
Butylated Hydroxytoluene – BHT
2,6-di-tert-butyl-para-cresol
2,6-di-tert-Butyl-methylphenol
2,6-ditertbutyl-4-methylphenol
2,6-di-t butyl-4-methylphenol
2.6-di-t-butyl-4-methylphenol
2,6-di-tert-butyl-4methylphenol
2,6-di-tert-butyl4-methylphenol
2,6-di-tertbutyl-4-methylphenol
2,6-ditert.butyl-4-methylphenol
2.6-di-tert-butyl-4-methylenol
Butylated hydroxyl toluene (BHT)
2,6-Di(tert-butyl)hydroxytoluene
2,6-di(t-butyl)-4-methylphenol
2,6-di-t- butyl-4-methylphenol
2,6-di-t-butyl 4-methyl phenol
2,6-di-t-butyl-4-methyl phenol
2,6-di-t-butyl-4-methyl-phenol
3,5-di-t-butyl-4-hydroxytoluene
Pharmakon1600-01600716
2,1-dimethylethyl)-4-methylphenol
2,6-di-tert-butyl 4-methylphenol
2,6-di-tert-butyl-4 methylphenol
2,6-di-tert-butyl4-methyl phenol
2,6-di-tert.butyl-4-methylphenol
2,6-ditert.-butyl-4-methylphenol
2.6-di-tert-butyl-4-methylphenol
4-methyl-2,6-di-tert.butylphenol
2,6-di-ter-butyl-4-methyl-phenol
2,6-Di-tert.-Butyl4-methylphenol
2,6-ditertiarybutyl-4-methylphenol
2.6-di- t-butyl- 4-methylphenol
2,6 -di-tert-butyl-4-methylphenol
2,6-di(tert-butyl)-4-methylphenol
2,6-Di-tert-butyl-p-cresol, 8CI
2,6-di-tert.-butyl-4-methylphenol
2,6-di-tert-butyl-p-cresol (BHT)
2,6-Di-tert-butyl-para-methylphenol
2,6-di-tert. butyl-4-methyl phenol
2,6-Di-(tert-butyl)-4-methylphenol
4-Hydroxy-3,5- Di-tert-Butyltoluene
Phenol, 2,6-di-tert-butyl-4-methyl-
2,6-Di-tert-butyl-4-methylphenol (BHT)
BUTYLATED HYDROXYTOLUENE CRYSTALLINE
SBI-0052890.P002
2,6-Di-tert-butyl-4-methylphenol, >=99%
Butylated hydroxytoluene, >=99%, FCC, FG
Phenol,6-bis(1,1-dimethylethyl)-4-methyl-
ST50214443
2,6-bis-(1,1-dimethylethyl)-4-methylphenol
4-Methyl-2,6- di(1,1-dimethylethyl)phenol
2,6-Di-tert-butyl-1-hydroxy-4-methyl benzene
Phenol, 3,5-bis(1,1-dimethylethyl)-4-methyl-
2,6-Bis(1,1-dimethylethyl)-4-methylphenol, 9CI
2,6-Di-tert-butyl-4-methylphenol, puriss., 99%
BENZENE,1,3-DITERT.BUTYL,2-HYDROXY,5-METHYL
2,6-D[(CH3)3C]2C6H2(CH3)OHi-tert-butyl-p-cresol
2,6-Di-tert-butyl-4-methylphenol, purum, >=99.0% (GC)
2,6-Di-tert-butyl-4-methylphenol, >=99.0% (GC), powder
2,6-Di-tert-butyl-4-methylphenol, SAJ first grade, >=99.0%
2,6-Di-tert-butyl-4-methylphenol, tested according to Ph.Eur.
3,5-Di-tert-4-butylhydroxytoluene (BHT), analytical standard
Butylhydroxytoluene, European Pharmacopoeia (EP) Reference Standard
2,6-Di-tert-butyl-4-methylphenol, certified reference material, TraceCERT(R)
Butylated Hydroxytoluene, Pharmaceutical Secondary Standard; Certified Reference Material
Butylated hydroxytoluene, United States Pharmacopeia (USP) Reference Standard
• Ionol CP-antioxidant
• 1-Hydroxy-4-methyl-2,6-di-tertbutylbenzene
• 2,6-Bis(1,1-dimethylethyl)-4- methylphenol
• 2,6-Di-t-butyl-4-methylphenol
• 2,6-Di-t-butyl-p-cresol
• 2,6-Di-terc.butyl-p-kresol
• 2,6-Di-terc.butyl-p-kresol [Czech]
• 2,6-Di-tert-butyl-1-hydroxy-4- methylbenzene
• 2,6-Di-tert-butyl-4-cresol
• 2,6-Di-tert-butyl-4-hydroxytoluene
• 2,6-Di-tert-butyl-4- methylhydroxybenzene
• 2,6-Di-tert-butyl-4-methylphenol
• 2,6-Di-tert-butyl-p-cresol
• 2,6-Di-tert-butyl-p-methylphenol
• 3,5-Di-tert-butyl-4-hydroxytoluene
• 4-Hydroxy-3,5-di-tert-butyltoluene
• 4-Methyl-2,6-di-terc. Butylfenol
• 4-Methyl-2,6-di-terc. butylfenol [Czech]
• 4-Methyl-2,6-di-tert-butylphenol
• 4-Methyl-2,6-tert-butylphenol
• AI3-19683
• AO 29
• AO 4
• AO 4K
• AOX 4
• AOX 4K
• Advastab 401
• Agidol
• Agidol 1
• Alkofen BP
• Antioxidant 264
• Antioxidant 29
• Antioxidant 30
• Antioxidant 4
• Antioxidant 4K
• Antioxidant DBPC
• Antioxidant KB
• Antioxidant MPJ
• Antioxidant T 501
• Antox QT
• Antrancine 8
• BAT
• BHT
• BHT (food grade)
• BHT 264
• BUKS
• Butylated hydroxytoluene
• Butylated hydroxytoluol
• Butylhydroxytoluene
• Butylohydroksytoluenu
• Butylohydroksytoluenu [Polish]
• CAO 1
• CAO 3
• CCRIS 103
• Caswell No. 291A
• Catalin antioxydant 1
• Catalin cao-3
• Chemanox 11
• DBPC
• DBPC (technical grade)
• Dalpac
• Deenax
• Di-tert-butyl-p-cresol
• Di-tert-butyl-p-cresol (VAN)
• Di-tert-butyl-p-methylphenol
• Dibunol
• Dibutylated hydroxytoluene
• EINECS 204-881-4
• EPA Pesticide Chemical Code
• 022105
• FEMA No. 2184
• HSDB 1147
• Impruvol
• Ionol
• Ionol (antioxidant)
• Ionol 1
• Ionol CP
• Ionole
• Kerabit
• NCI-C03598
• NSC 6347
• Nocrac 200
• Nonox TBC
• P 21
• P21
• Parabar 441
• Paranox 441
• Phenol, 2,6-bis(1,1-dimethylethyl)-4- methyl-
• Stavox
• Sumilizer BHT
• Sustane
• Sustane BHT
• Swanox BHT
• Tenamen 3
• Tenamene 3
• Tenox BHT
• Tonarol
• Topanol
• Topanol O
• Topanol OC
• Toxolan P
• Vanlube PC
• Vanlube PCX
• Vianol
• Vulkanox KB
• o-Di-tert-butyl-p-methylphenol
BHT, sentetik antioksidanlar sınıfına giren BHA ve BHT; yaygın olarak kullanılan gıda katkı maddeleri olup, yağda aşırı derece çözünmekte, suda ise çözünmemektedir. BHA ve BHT; katı, sıvı yağlar ve sıvı yağ içeren gıdalarda ransiditeyi yavaşlatmakta; çeşitli tahıl ürünleri, sakız, patates cipsi gibi bitkisel kaynaklı yağların kullanıldığı ürünlerde, bu ürünlerin havaya maruz kalmalarından kaynalanabilecek renk, aroma veya tekstür değişimlerini önlemektedir. Bu ürünlerin dışında, BHT ayrıca vitamin ve mineral katkı preparatlarında dolgu maddesi olarakta kullanılmaktadır.
Son yıllarda daha sağlıklı beslenmek isteyen insanlar, doymuş hayvansal yağlar yerine doymamış ve çoklu doymamış yağlar içeren ürünleri tercih etmektedir. Ne yazık ki, doymamış yağ içeren ürünler, oksidasyona daha açık olup, daha kolay bozulmaktadır. İstenmeyen bu oksidasyon sürecinin önlenmesi için çeşitli teknolojilerin (vakumlama, ambalajlama vb.) faydası görülmekle beraber, ürünlere antioksidanları ilavesi; ürünlerin raf ömrünün artırılması için en etkili seçeneklerden birini oluşturmaktadır. Beraber kullanıldığında sinerjik etki gösteren BHT ve BHA; özellikle fındık ve fındık içeren ürünlerde çok güzel sonuçlar vermektedir.