CALCIUM LACTATE
CALCIUM LACTATE
Calcium lactate is a white crystalline salt with formula C6H10CaO6, consisting of two lactate anions H3C(CHOH)CO−2 for each calcium cation Ca2+.
Calcium lactate is a food additive that’s typically added to a wide variety of foods to enhance their texture and flavor or help extend their shelf life.
Calcium lactate’s E number is E327.
CAS Number: 814-80-2
EC Number: 212-406-7
Molecular Formula: C6H10CaO6
Molar Mass: 218.22 g/mol
Synonyms: calcium lactate, 814-80-2, Calphosan, Calcium dilactate, calcium 2-hydroxypropanoate, Hemicalcium L-lactate, Conclyte calcium, Lactic acid, calcium salt (2:1), 2-Hydroxypropanoic acid calcium salt, 63690-56-2, calcium;2-hydroxypropanoate, Propanoic acid, 2-hydroxy-, calcium salt (2:1), Calcium lactate anhydrous, Calcium 2-hydroxypropanoate (1:2), 5743-48-6, Calcium Lactate [USAN:JAN], CCRIS 3669, HSDB 976, Calcium (as lactate), calcium bis(2-hydroxypropanoate), EINECS 212-406-7, Calcium lactate, anhydrous, Ins No.327, UNII-2URQ2N32W3, AI3-04468, 2URQ2N32W3, 28305-25-1, CALCIUM LACTATE (1 G), DTXSID0020236, INS-327, INS-327-, EINECS 227-266-2, Calcium lactate [II], Calcium lactate [MI], Calcium lactate [FCC], Calcium lactate [HSDB], Calcium lactate [INCI], Calcium lactate (1:2), Calcium lactate [VANDF], E-327, EC 212-406-7, Calcium lactate [WHO-DD], DTXCID60236, Calcium (as lactate) [VANDF], Ca lactate, C3H6O3.1/2Ca, Calcium (S)-2-hydroxy-propanate, CAS-814-80-2, (+/-)-Lactic acid, calcium salt (2:1), calcium dl-lactate, C3-H6-O3.1/2Ca, L(+)-calcium lactate, Propanoic acid, 2-hydroxy-, calcium salt, C3H6O3.xCa, Lactic acid, calcium salt, SCHEMBL4319, C3-H6-O3.x-Ca, CHEMBL2106111, HY-B2227A, CALCIUM LACTATE [USP-RS], Lactic acid calcium salt (2:1), MKJXYGKVIBWPFZ-UHFFFAOYSA-L, AMY37027, Tox21_201378, Tox21_302896, Bis(2-hydroxypropanoic acid) calcium, AKOS015837558, CALCIUM LACTATE [EP MONOGRAPH], DB13231, LS-2396, NCGC00256365-01, NCGC00258929-01, LS-192480, 2-Hydroxypropanoic acid calcium salt (2:1), CS-0021602, FT-0623403, FT-0652809, F16480, CALCIUM LACTATE ANHYDROUS [USP MONOGRAPH], CALCIUM LACTATE, ANHYDROUS [EP IMPURITY], A840142, Propanoic acid, 2-hydroxy-, calcium salt (2;1), Q419693, 227-266-2 [EINECS], 2URQ2N32W3, 5743-48-6 [RN], 814-80-2 [RN], Bis(2-hydroxypropanoate) de calcium [French] [ACD/IUPAC Name], Calcium bis(2-hydroxypropanoate) [ACD/IUPAC Name], Calcium dilactate, CALCIUM D-LACTATE, Calcium lactate [JP15] [Trade name] [USP], CALCIUM LACTATE, L-, Calciumbis(2-hydroxypropanoat) [German] [ACD/IUPAC Name], Propanoic acid, 2-hydroxy-, calcium salt (2:1) [ACD/Index Name], [(2-HYDROXYPROPANOYL)OXY]CALCIO 2-HYDROXYPROPANOATE, [28305-25-1] [RN], 145179-24-4 [RN], 16127-59-6 [RN], 240-289-2 [EINECS], 28305-25-1 [RN], 2-Hydroxypropanoic acid calcium salt, 3-imidazo[1,2-a]pyrazinecarboxaldehyde, 5497-50-7 [RN], 5743-47-5 [RN], 63690-56-2 [RN], Calcet, CALCIUM (S)-2-HYDROXYPROPIONATE, calcium 2-hydroxypropanoate, Calcium 2-hydroxypropanoate (1:2), calcium and 2-hydroxypropanoate, Calcium Lactate [USAN:JAN] [JAN] [USAN], CALCIUM LACTATE, ANHYDROUS, calciumlactate, Calphosan, Conclyte calcium, Hemicalcium L-lactate, Imidazo[1,2-a]pyrazine-3-carbaldehyde [ACD/IUPAC Name], lactic acid calcium salt, Lactic Acid Calcium Salt (2:1), MFCD00035548, MFCD00065401, MFCD00078198, UNII:2URQ2N32W3
Calcium lactate is a white crystalline salt with formula C6H10CaO6, consisting of two lactate anions H3C(CHOH)CO−2 for each calcium cation Ca2+.
Calcium lactate forms several hydrates, the most common being the pentahydrate C6H10CaO6·5H2O.
Calcium lactate is used in medicine, mainly to treat calcium deficiencies; and as a food additive with E number of E327.
Some cheese crystals consist of calcium lactate.
Calcium lactate is a food additive that’s typically added to a wide variety of foods to enhance their texture and flavor or help extend their shelf life.
Calcium lactate can also be used as an ingredient in medications or certain types of calcium supplements.
Calcium lactate is a black or white crystalline salt made by the action of lactic acid on calcium carbonate.
Calcium lactate is used in foods (as an ingredient in baking powder) and given medicinally.
Calcium lactate’s E number is E327.
Calcium lactate is created by the reaction of lactic acid with calcium carbonate or calcium hydroxide.
Calcium lactate is often found in aged cheeses.
Small crystals of Calcium lactate precipitate out when lactic acid is converted into a less soluble form by the bacteria active during the ripening process.
In medicine, calcium lactate is most commonly used as an antacid and also to treat calcium deficiencies.
Calcium lactate can be absorbed at various pHs and does not need to be taken with food for absorption for these reasons.
Calcium lactate is added to sugar-free foods to prevent tooth decay.
When added to chewing gum containing xylitol, Calcium lactate increases the remineralization of tooth enamel.
Calcium lactate is also added to fresh-cut fruits such as cantaloupes to keep them firm and extend their shelf life, without the bitter taste caused by calcium chloride, which can also be used for this purpose.
Calcium lactate is a calcium salt.
Calcium lactate is a less concentrated form of calcium, and seems to be less bioavailable than other forms of supplemental calcium.
This means Calcium lactate less available to be absorbed and used by your body.
For this reason, calcium lactate is not the most practical form of oral supplemental calcium.
Calcium lactate is often used as a food additive to enhance the calcium content of foods, replace other salts, or increase the overall pH (that is, decrease the acidity) of the food.
This article looks at the supplement calcium lactate and what the research says about Calcium lactate health benefits.
Calcium lactate also discusses side effects, dosage, and other calcium supplement options.
Calcium lactate is a salt that consists of two lactate anions for each calcium cation (Ca2+).
Calcium lactate is prepared commercially by the neutralization of lactic acid with calcium carbonate or calcium hydroxide.
Approved by the FDA as a direct food substance affirmed as generally recognized as safe, calcium lactate is used as a firming agent, flavoring agent, leavening agent, stabilizer, and thickener.
Calcium lactate is also found in daily dietary supplements as a source of calcium.
Calcium lactate is also available in various hydrate forms, where calcium lactate pentahydrate is the most common.
Calcium Lactate is a dairy-free, vegan tablet that helps maintain healthy bone density.
Calcium lactate is an excellent source of calcium and a good source of magnesium.
The conversion of calcium lactate into lactic acid is generally done with sulfuric acid, thus resulting in the generation of gypsum (calcium sulfate) as a solid by-product, which, by Calcium lactate accumulation, constitutes an environmental issue.
Calcium lactate is a white or cream, almost odorless food additive derived from lactic acid, a compound that cells naturally create when trying to produce energy in low oxygen conditions.
Calcium lactate produced commercially by neutralizing lactic acid with calcium carbonate or calcium hydroxide and most often used to stabilize, thicken, flavor, firm, or leaven foods.
Calcium lactate is either referred to by Calcium lactate name or E number — E327.
Calcium lactate can also be added to calcium supplements or medications used to treat acid reflux, bone loss, a poorly functioning parathyroid gland, or certain muscle diseases.
Calcium lactate may also be added to animal feed or used to treat water to make Calcium lactate suitable for human consumption.
Despite its similar name, calcium lactate does not contain lactose.
As such, Calcium lactate safe for people with lactose intolerance.
Calcium lactate (Food Acid 327) is a white crystalline salt made by the action of lactic acid on calcium carbonate.
Calcium lactate is used in foods (as a baking powder) and given medicinally.
Calcium lactate is often found in aged cheeses.
Small crystals of Calcium lactate precipitate out when lactic acid is converted into a less soluble form by the bacteria active during the ripening process.
In medicine, calcium lactate is most commonly used as an antacid and also to treat calcium deficiencies.
Calcium lactate can be absorbed at various pHs and does not need to be taken with food for absorption for these reasons.
Calcium Lactate is a premium quality product and an extract of Lactic Acid.
Calcium lactate works well in the production of Caviar, pearls, spaghetti and spheres using spherification techniques.
Calcium Lactate can also be used to coat fresh fruit and cantaloupes to keep them firm and extend the shelf life.
Calcium lactate a white non-hygroscopic salt and is a recommended source of calcium.
Calcium lactate provides calcium salts in a soluble form to react with Alginate, Gellan or certain kinds of Carrageenan which permit gel formation without heating.
Calcium lactate taste is more discreet than Calcium Chloride (salty and sometimes bitter).
Calcium Lactate is recommended for all reactions of inverse spherification and reacts where Alginate and Calcium sources are intimately mixed when in a diffuse setting or full contact gelling.
Calcium Lactate also works well in the production of drops, Caviar pearls and all shapes of spaghetti by immersion of an Alginate solution in a Calcium setting bath.
Suitable for Vegans & Vegetarians, Non-GMO, Gluten Free, Kosher Friendly, Halal Friendly.
Calcium lactate is registered under the REACH Regulation but is not currently being manufactured in and / or imported to the European Economic Area.
Calcium lactate is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Calcium Lactate contains 20% of the daily recommended value of calcium (from calcium lactate and stearate) and 12% of the daily recommended value of magnesium.
Calcium lactate is a salt that consists of two lactate anions for each calcium cation (Ca2+).
Calcium lactate is prepared commercially by the neutralization of lactic acid with calcium carbonate or calcium hydroxide.
Approved by the FDA as a direct food substance affirmed as generally recognized as safe, calcium lactate is used as a firming agent, flavoring agent, leavening agent, stabilizer, and thickener.
Calcium lactate is also found in daily dietary supplements as a source of calcium.
Calcium lactate is also available in various hydrate forms, where calcium lactate pentahydrate is the most common.
Calcium lactate is a mineral that is used to treat or prevent low blood calcium levels (hypocalcemia) in people who do not get enough calcium from food.
Calcium lactate is also used in the treatment of conditions such as osteoporosis, disorders of the parathyroid gland, or certain muscle problems.
Calcium lactate may also be used for purposes not listed in this medication guide.
Calcium lactate is commonly used as a food additive in packaged foods, such as:
Nectars,
Jams, jellies, and marmalades,
Butter, margarine, and other types of fats used for cooking or frying,
Canned fruits and vegetables,
Beer.
Calcium lactate sometimes also added to fresh foods, such as mozzarella cheese, fresh pastas, or precut fruit to help them maintain their firmness or extend their shelf life.
You can tell whether a food contains calcium lactate by looking for Calcium lactate on the ingredient label.
Calcium lactate may also be labeled as E327.
Applications of Calcium lactate:
Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or doctor.
No supplement is intended to treat, cure, or prevent disease.
Calcium is the most abundant mineral in the body.
Calcium lactate is required for bone health and for heart, muscle, and nerve function.
In the body, blood calcium levels remain relatively consistent and unchanged.
Calcium is acquired from dietary sources.
Apart from calcium for bone health, additional possible benefits of calcium lactate supplementation include benefits to heart health, oral health, and exercise performance.
Heart Health:
An older study examined the effect of calcium lactate supplementation on cholesterol in 43 people with hyperlipidemia and previous viral inflammation of the liver.
The study participants were divided into a test group and a control (placebo) group.
The test group was given calcium lactate and vitamin C three times a day for four weeks.
After four weeks, Calcium lactate was found that the test group had decreased total cholesterol levels by 4%.
Additionally, the supplementation did not cause side effects.
However, there were no statistically significant changes of other cholesterol markers.
This study shows promise for calcium lactate supplementation on heart health.
However, Calcium lactate was small and used a relatively low dose of calcium lactate.
Additional studies are needed to validate the role of calcium lactate supplementation in relation to heart health.
Oral Health:
A study looked at whether adding calcium lactate to xylitol chewing gum helps remineralize lesions on tooth enamel.
Artificial lesions were made on enamel slabs of human extracted teeth and worn by 10 volunteers.
Another 10 were used as controls and stored in a humidifier.
The study participants wore the enamel slabs in one of the following ways:
Without chewing gum
With chewing gum containing xylitol and calcium lactate
With chewing gum containing only xylitol
They did this four times a day for two weeks.
Remineralization was found to be greater after chewing xylitol and calcium lactate gum than in the other groups.
This led researchers to conclude that Calcium lactate might increase remineralization of tooth enamel surfaces.
A 2014 study looked at the ability of a calcium lactate pre-rinse to increase fluoride protection against tooth enamel erosion.
The researchers found that the pre-rinse followed by a fluoride rinse significantly decreased surface loss of enamel when used before an erosive challenge.
However, researchers of an earlier study on calcium lactate pre-rinse found that Calcium lactate did not significantly affect plaque fluoride concentration under any condition.
The mixed results and small sample size of these studies means further research is needed before calcium lactate can be recommended for oral health.
Pharmaceutical Applications:
Calcium lactate is used as a bioavailability enhancer and nutrient supplement in pharmaceutical formulations.
A spray-dried grade of calcium lactate pentahydrate has been used as a tablet diluent in direct compression systems, and has been shown to have good compactability.
The properties of the pentahydrate form have been considered superior to those of calcium lactate trihydrate when used in direct compression tablet formulations.
Tablet properties may be affected by the hydration state of the calcium lactate and particle size of Calcium lactate: reducing particle size increased crushing strength, whereas storage of tablets at elevated temperature resulted in dehydration accompanied by a reduction in crushing strength.
Calcium lactate has also been used as the source of calcium ions in the preparation of calcium alginate microspheres for controlled- release delivery of active agents.
Calcium lactate has been shown to result in lower calcium concentrations in the finished microspheres when compared with calcium acetate.
Therapeutically, calcium lactate has been used in preparations for the treatment of calcium deficiency.
Uses of Calcium lactate:
Calcium Lactate is the calcium salt of lactic acid which is soluble in water.
Calcium lactate has a solubility of 3.4 g/100 g of water at 20°c and is very soluble in hot water.
Calcium lactate is available as a monohydrate, trihydrate, and pentahydrate. the trihydrate and pentahydrate have solubili- ties of 9 g in 100 ml of water at 25°c.
Calcium lactate contains approximately 14% calcium.
Calcium lactate is used to stabilize and improve the texture of canned fruits and vegetables by converting the labile pectin to the less solu- ble calcium pectate.
Calcium lactate thereby prevents structural collapse during cooking.
Calcium lactate is used in angel food cake, whipped toppings, and meringues to increase protein extensibility which results in an increase of foam volume.
Calcium lactate is also used in calcium fortified foods such as infant foods and is used to improve the properties of dry milk powder.
Calcium lactate is an oral calcium salt used to prevent or treat low blood calcium levels in people who do not get enough calcium from their diet, patients with osteoporosis, weak bones, decreased parathyroid gland activity.
Calcium lactate is used as a food preservative and calcium supplement.
Calcium lactate is also used in dentifrices, respirator filters, buffering agents, food firming agents, and gelling salts for low methoxypectin.
Calcium lactate is used to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets.
Calcium lactate may be used to treat conditions caused by low calcium levels such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany).
Calcium lactate may also be used in certain patients to make sure they are getting enough calcium (such as women who are pregnant, nursing, or postmenopausal, people taking certain medications such as phenytoin, phenobarbital, or prednisone).
Calcium plays a very important role in the body.
Calcium lactate is necessary for normal functioning of nerves, cells, muscle, and bone.
If there is not enough calcium in the blood, then the body will take calcium from bones, thereby weakening bones.
Having the right amount of calcium is important for building and keeping strong bones.
Medicine:
Calcium lactate has several uses in human and veterinary medicine.
Calcium lactate is used in medicine as an antacid.
Calcium lactate is also used to treat hypocalcaemia (calcium deficiencies).
Calcium lactate can be absorbed at various pHs, thus Calcium lactate does not need to be taken with food.
However, in this use Calcium lactate has been found to be less convenient than calcium citrate.
In the early 20th century, oral administration of calcium lactate dissolved in water (but not in milk or tablets) was found to be effective in prevention of tetany in humans and dogs with parathyroid insufficiency or who underwent parathyroidectomy.
Calcium lactate is also found in some mouth washes and toothpaste as an anti-tartar agent.
Calcium lactate (or other calcium salts) is an antidote for soluble fluoride ingestion and hydrofluoric acid.
Food industry:
Calcium lactate is a food additive classified by the United States FDA as Generally Recognized as Safe (GRAS), for uses as a firming agent, a flavor enhancer or flavoring agent, a leavening agent, a nutritional supplement, and a stabilizer and thickener.
Calcium lactate is also known as cheese lactate because Calcium lactate coagulates milk, making the chhena used in the production of paneer cheese.
Chhena is also used to make various sweets and other milk proteins.
Calcium lactate is an ingredient in some baking powders containing sodium acid pyrophosphate.
Calcium lactate provides calcium in order to delay leavening.
Calcium lactate is added to sugar-free foods to prevent tooth decay.
When added to chewing gum containing xylitol, Calcium lactate increases the remineralization of tooth enamel.
Calcium lactate is also added to fresh-cut fruits, such as cantaloupes, to keep them firm and extend their shelf life, without the bitter taste caused by calcium chloride, which can also be used for this purpose.
Calcium lactate is used in molecular gastronomy as a flavorless fat-soluble agent for plain and reverse spherification.
Calcium lactate reacts with sodium alginate to form a skin around the food item.
Animal feeds:
Calcium lactate may be added to animal rations as a source of calcium.
Chemistry:
Calcium lactate was formerly an intermediate in the preparation of lactic acid for food and medical uses.
The impure acid from various sources was converted to calcium lactate, purified by crystallization, and then converted back to acid by treatment with sulfuric acid, which precipitated the calcium as calcium sulfate.
This method yielded a purer product than would be obtained by distillation of the original acid.
Recently ammonium lactate has been used as an alternative to calcium in this process.
Water treatment:
Calcium lactate has been considered as a coagulant for removing suspended solids from water, as a renewable, non-toxic, and biodegradable alternative to aluminum chloride AlCl3.
Bioconcrete:
Addition of calcium lactate substantially increases the compressive strength and reduces water permeability of bioconcrete, by enabling bacteria such as Enterococcus faecalis, Bacillus cohnii, Bacillus pseudofirmus and Sporosarcina pasteurii to produce more calcite.
Consumer Uses:
Calcium lactate is used in the following products: cosmetics and personal care products.
Other release to the environment of Calcium lactate is likely to occur from: indoor use as processing aid.
Widespread uses by professional workers:
Calcium lactate is used in the following products: plant protection products, polishes and waxes and washing & cleaning products.
Calcium lactate is used in the following areas: agriculture, forestry and fishing.
Other release to the environment of Calcium lactate is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use as processing aid.
Uses at industrial sites:
Calcium lactate is used in the following products: metal surface treatment products, non-metal-surface treatment products and semiconductors.
Calcium lactate is used for the manufacture of: chemicals and electrical, electronic and optical equipment.
Release to the environment of Calcium lactate can occur from industrial use: in processing aids at industrial sites and as processing aid.
Features of Calcium lactate:
Calcium Lactate is a dairy-free, vegan tablet that helps maintain healthy bone density.
Calcium lactate is an excellent source of calcium and a good source of magnesium such as:
Supports muscle and nerve function,
Supports normal functions of cells and cell membranes,
Supports normal blood clotting process,
Supports proper functioning of enzyme systems,
Supports and helps maintain healthy bone density and remodeling,
Provides support in the immune system response function,
Adequate calcium as part of a healthful diet, along with physical activity, may reduce the risk of osteoporosis in later life,
Excellent source of calcium,
Good source of magnesium,
Vegan, vegetarian, gluten-free, non-dairy, non-soy.
Calcium Lactate for Maintaining Healthy Bone Density:
Bone remodeling (bone turnover) is a continuous cycle of bone breakdown by osteoclasts in areas of the body where bone isn’t needed, and bone rebuilding handled by osteoblasts.
In other words, bone itself undergoes continuous remodeling, with constant resorption and deposition of calcium into new bone.
The balance between bone resorption and deposition is important for healthy bones, and Calcium lactate changes with age.
Both calcium and magnesium are critical to bone health.
99% of the body’s calcium supply is stored in the bones and teeth where Calcium lactate supports normal and healthy bone structure and function.
Taking an additional calcium supplement can help increase the body’s supply of calcium.
Magnesium also contributes to the structural development of bone, with 50% to 60% present in the bones.
In particular, magnesium is involved in bone formation and influences the activities of osteoblasts (bone rebuilding) and osteoclasts (bone breakdown).
Calcium Lactate for Immune System Health:
Both calcium and magnesium are involved in supporting aspects of the body’s healthy immune system.
Calcium (Ca2+) signals control various aspects of cell functioning such as T lymphocytes.
T lymphocytes – along with other immune cells – respond to foreign particles in the body.
These T cells, which are made in bone marrow and are essential for cell-mediated immunity, need a sustained Calcium ion flow for regulation, activation, and proliferation.
Emerging research indicates magnesium may also play a role in the human immune system response such as through magnesium transporters.
A number of magnesium transporters have been identified in immune cells such as Magnesium transporter 1 (MagT1).
MagT1 is expressed in the spleen, thymus, T and B lymphocytes, suggesting that MagT1 may be involved in the human immune system functions.
Benefits of Calcium lactate:
Possible Health Benefits:
Very few studies have specifically researched the health benefits of calcium lactate.
That said, Calcium lactate can be used as a main source of calcium in calcium supplements, and some studies link calcium-rich diets to stronger and healthier bones, though research is inconsistent.
Though sourcing your calcium directly from foods remains the best way to ingest this mineral, supplements can be a helpful tool for those who are unable to get enough calcium through their diet alone.
When consumed as a supplement, calcium lactate may provide benefits similar to those associated with other calcium supplements, including:
Stronger bones.
When taken together with vitamin D, calcium supplements are thought to contribute to the development and maintenance of strong, healthy bones.
Reduced blood pressure.
Calcium-rich diets may help slightly lower systolic blood pressure (the top number) in those with elevated blood pressure.
However, there seems to be little benefit among people with normal blood pressure levels.
Protection against preeclampsia.
High calcium intakes during pregnancy may lower the risk of preeclampsia, a serious complication that affects up to 14% of pregnancies worldwide.
Protection against colon cancer.
Studies suggest that a high calcium intake from foods or supplements may reduce colon cancer risk.
Still, more research is needed to confirm these findings.
Older studies further suggest that chewing gums containing calcium lactate together with the artificial sweetener xylitol may help protect against cavities.
Yet, more research is needed to confirm these results.
Gram per gram, calcium lactate tends to provide smaller amounts of calcium than more popular forms of calcium, such as calcium carbonate and calcium citrate.
Therefore, to contain equivalent amounts of calcium, calcium lactate supplements may be larger than other types of calcium supplements, potentially making them harder to swallow.
You may also need to take more pills.
Calcium lactate is likely less constipating than calcium carbonate, but Calcium lactate doesn’t provide any additional benefits beyond those associated with calcium citrate.
This explains why Calcium lactate seldom used as a main ingredient in calcium supplements.
Typical Properties of Calcium lactate:
The lactate ion is chiral, with two enantiomers, D (−,R) and L (+,S).
The L isomer is the one normally synthesized and metabolized by living organisms, but some bacteria can produce the D form or convert the L to D.
Thus calcium lactate also has D and L isomers, where all anions are of the same type.
Some synthesis processes yield a mixture of the two in equal parts, resulting in the DL (racemic) salt.
Both the L and the DL forms occur as crystals on the surface of aging Cheddar cheese.
The solubility of calcium L-lactate in water increases significantly in presence of d-gluconate ions, from 6.7 g/dl) at 25 °C to 9.74 g/dl or more.
Paradoxically, while the solubility of calcium L-lactate increases with temperature from 10 °C (4.8 g/dl) to 30 °C (8.5 g/dl), the concentration of free Ca2+ ions decreases by almost one half.
This is explained as the lactate and calcium ions becoming less hydrated and forming a complex C3H5O3Ca+.
The DL (racemic) form of the salt is much less soluble in water than the pure L or D isomers, so that a solution that contains as little as 25% of the D form will deposit racemic DL-lactate crystals instead of L-lactate.
The pentahydrate loses water in a dry atmosphere between 35 and 135 °C, being reduced to the anhydrous form and losing Calcium lactate crystalline character.
The process is reversed at 25 °C and 75% relative humidity.
Pharmacodynamics of Calcium lactate:
Both components of calcium lactate, calcium ion and lactic acid, play essential roles in the human body as a skeletal element an energy source, respectively.
Mechanism of action of Calcium lactate:
In aqueous environments such as the gastrointestinal (GI) tract, calcium lactate will dissociate into calcium cation and lactic acid anions, the conjugate base of lactic acid.
Lactic acid is a naturally-occurring compound that serves as fuel or energy in mammals by acting as an ubiquitous intermediate in the metabolic pathways.
Lactic acid diffuses through the muscles and is transported to the liver by the bloodstream to participate in gluconeogenesis.
Absorption of Calcium lactate:
In order to be absorbed, calcium must be in Calcium lactate freely soluble form (Ca2+) or bound to a soluble organic molecule.
Calcium absorption mainly occurs at the duodenum and proximal jejunum due to more acidic pH and the abundance of the calcium binding proteins.
The mean calcium absorption is about 25% of calcium intake (range is 10 – 40%) in the small intestine, and is mediated by both passive diffusion and active transport.
Preparation of Calcium lactate:
Calcium lactate can be prepared by the reaction of lactic acid with calcium carbonate or calcium hydroxide.
Since the 19th century, the salt has been obtained industrially by fermentation of carbohydrates in the presence of calcium mineral sources such as calcium carbonate or calcium hydroxide.
Fermentation may produce either D or L lactate, or a racemic mixture of both, depending on the type of organism used.
General Manufacturing Information of Calcium lactate:
Industry Processing Sectors:
Wholesale and Retail Trade
Handling and storage of Calcium lactate:
Advice on protection against fire and explosion:
Provide appropriate exhaust ventilation at places where dust is formed.
Hygiene measures:
General industrial hygiene practice.
Conditions for safe storage, including any incompatibilities:
Storage conditions:
Keep container tightly closed in a dry and well-ventilated place.
Store in cool place.
Storage class:
Storage class (TRGS 510): 11: Combustible Solids
Stability and reactivity of Calcium lactate:
Reactivity:
No data available
Chemical stability:
Stable under recommended storage conditions.
Possibility of hazardous reactions:
No data available
Conditions to avoid:
No data available
Incompatible materials:
Strong oxidizing agents
Safety and Precautions of Calcium lactate:
According to the Food and Drug Administration (FDA), calcium lactate is generally recognized as safe (GRAS) and may be added to all foods except infant foods and formulas.
Calcium lactate is considered a safe source of calcium in calcium supplements.
In addition, given that Calcium lactate contains less calcium than other forms, Calcium lactate less likely to cause the constipation or upset stomach commonly associated with supplements containing calcium carbonate.
That said, Calcium lactate important to note that excess intakes of calcium lactate may result in hypercalcemia, a condition characterized by dangerously high blood levels of calcium, which may cause heart or kidney problems.
Calcium lactate best to not exceed the safe daily upper intake levels (UL) of 2,500 mg per day for adults under 50 years old and pregnant or breastfeeding people, 2,000 mg per day for those 51 years or older, and 3,000 mg per day for pregnant or breastfeeding people younger than 19.
Calcium lactate supplements may also interact with some medications, including diuretics, antibiotics, and anti-seizure drugs.
Therefore, Calcium lactate best to seek guidance from your healthcare provider before taking such supplements.
First aid measures of Calcium lactate:
If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
In case of skin contact:
Wash off with soap and plenty of water.
In case of eye contact:
Flush eyes with water as a precaution.
If swallowed:
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Firefighting measures of Calcium lactate:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from Calcium lactate or mixture:
Carbon oxides
Calcium oxide
Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Further information:
No data available
Accidental release measures of Calcium lactate:
Personal precautions, protective equipment and emergency procedures:
Avoid dust formation.
Avoid breathing vapors, mist or gas.
Environmental precautions:
No special environmental precautions required.
Methods and materials for containment and cleaning up:
Sweep up and shovel.
Keep in suitable, closed containers for disposal.
Identifiers of Calcium lactate:
CAS Number: 814-80-2
ChEMBL: ChEMBL2106111
ChemSpider: 12592
DrugBank: DB13231
ECHA InfoCard: 100.011.278
EC Number: 212-406-7
E number: E327 (antioxidants, …)
PubChem CID: 13144
UNII: 2URQ2N32W3
CompTox Dashboard (EPA): DTXSID0020236
InChI: InChI=1S/2C3H6O3.Ca/c2*1-2(4)3(5)6;/h2*2,4H,1H3,(H,5,6);/q;;+2/p-2
Key: MKJXYGKVIBWPFZ-UHFFFAOYSA-L
InChI=1/2C3H6O3.Ca/c2*1-2(4)3(5)6;/h2*2,4H,1H3,(H,5,6);/q;;+2/p-2
Key: MKJXYGKVIBWPFZ-NUQVWONBAM
SMILES: [Ca+2].[O-]C(=O)C(O)C.[O-]C(=O)C(O)C
CAS number: 5743-47-5
EC number: 248-953-3
Grade: Ph Eur,BP,USP,E 327
Hill Formula: C₆H₁₀CaO₆*5H₂O
Molar Mass: 308.30 g/mol
HS Code: 2918 11 00
Molecular Formula: C6H10CaO6
Average mass: 218.218 Da
Monoisotopic mass: 218.010330 Da
ChemSpider ID: 12592
Properties of Calcium lactate:
Chemical formula: C6H10CaO6
Molar mass: 218.22 g/mol
Appearance: white or off-white powder, slightly efflorescent
Density: 1.494 g/cm3
Melting point: 240 °C (464 °F; 513 K) (anhydrous)
120 °C (pentahydrate)
Solubility in water: L-lactate, anhydrous, g/100 mL: 4.8 (10 °C), 5.8 (20 °C), 6.7 (25 °C), 8.5 (30 °C); 7.9 g/100 mL (30 °C)
Solubility: very soluble in methanol, insoluble in ethanol
Acidity (pKa): 6.0-8.5
Refractive index (nD): 1.470
Ignition temperature: 610 °C
Melting Point: 240 °C
pH value: 7 (50 g/l, H₂O, 20 °C)
Bulk density: 300 – 500 kg/m3
Solubility: 50 g/l
Molecular Weight: 218.22 g/mol
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 6
Rotatable Bond Count: 0
Exact Mass: 218.0103289 g/mol
Monoisotopic Mass: 218.0103289 g/mol
Topological Polar Surface Area: 121Ų
Heavy Atom Count: 13
Complexity: 53.5
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 2
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 3
Compound Is Canonicalized: Yes
Specifications of Calcium lactate:
Assay (complexometric; calculated on dried substance): 98.0 – 101.0 %
Identity (IR-spectrum): passes test
Identity (Calcium): passes test
Identity (Lactat): passes test
Appearance: white to almost white crystalline or granular powder
Appearance of solution (71 g/l; water): almost clear (≤ 6 NTU) and not more intense in colour than reference solution BY₆
Acidity or alkalinity: passes test
pH (71 g/l; water): 6.0 – 8.0
Chloride (Cl): ≤ 200 ppm
Fluoride (F): ≤ 30 ppm
Sulfate (SO₄): ≤ 400 ppm
Heavy metals (as Pb): ≤ 10 ppm
Al (Aluminium): ≤ 50 ppm
As (Arsenic): ≤ 3 ppm
Ba (Barium)*: ≤ 70 ppm
Fe (Iron): ≤ 50 ppm
Hg (Mercury): ≤ 1 ppm
Pb (Lead): ≤ 2 ppm
Magnesium and alcali salts: ≤ 1.0 %
Volatile fatty acids: passes test
Reducing substances: passes test
Residual solvents (ICH Q3C): excluded by production process
Loss on drying (125 °C): 22.0 – 27.0 %
Names of Calcium lactate:
Regulatory process names:
Calcium lactate
Calcium lactate
calcium lactate
IUPAC names:
calcium bis(2-hydroxypropanoate)
Preferred IUPAC name:
Calcium bis(2-hydroxypropanoate)
Other names:
calcium lactate 5-hydrate,
calcium lactate,
2-hydroxypropanoic acid
calcium salt pentahydrate
Other identifiers:
5743-48-6