PLASDONE S-630
PLASDONE S-630
PLASDONE S-630 acts as a tablet binder, ensuring proper tablet integrity, and aids in rapid disintegration upon contact with moisture, facilitating efficient drug release and absorption.
PLASDONE S-630’s applications extend beyond pharmaceuticals to coatings, adhesives, and personal care products due to its adhesive and film-forming properties.
PLASDONE S-630 copovidone is highly compressible, making it an excellent tablet binder for direct compression and dry granulation processes, resulting in tablets with high breaking force and low friability.
CAS Number: 25086-89-9
EC Number: 500-987-8
Synonyms: Polyvinylpyrrolidone-vinyl acetate copolymer, PVP/VA copolymer, Vinylpyrrolidone-vinyl acetate copolymer, Copovidone, Polyvidone-vinyl acetate copolymer, Povidone-vinyl acetate copolymer, Polyvinylpyrrolidone-co-vinyl acetate, PVP-VA copolymer, Vinylpyrrolidone-vinyl acetate polymer, Povidone-vinyl acetate polymer, PVPP-VA, Poly(N-vinylpyrrolidone)-co-vinyl acetate, VP-VA copolymer, Copolyvidone, PVP-vinyl acetate copolymer
PLASDONE S-630 is a copolymer of polyvinylpyrrolidone (PVP) and vinyl acetate.
PLASDONE S-630 is commonly used as a tablet binder and disintegrant in pharmaceutical formulations.
PLASDONE S-630 helps to bind the ingredients of a tablet together, ensuring proper tablet integrity, and also aids in the rapid disintegration of the tablet when it comes into contact with moisture.
This allows for efficient drug release and absorption in the body.
Additionally, PLASDONE S-630 may find applications in other areas such as coatings, adhesives, and personal care products due to PLASDONE S-630’s adhesive and film-forming properties.
PLASDONE S-630 is a pharmaceutical oral care polymer which has excellent bioadhesion properties and is a tougher, more flexible film former than PVP.
PLASDONE S-630 Copovidones a highly compressible powder, making it an excellent tablet binder for direct compression and dry granulation.
PLASDONE S-630 is often used with poorly compressible actives to improve tablet breaking force and lower friability.
More recently, these polymers have been used in solid dispersions to increase solubility and thereby increase bioavailability of poorly soluble APIs.
PLASDONE S-630 is a 60:40 linear, random copolymer of N-vinyl-2-pyrolidone (PVP) and vinyl acetate.
PLASDONE S-630 acts as a tablet binder in denture cleanser tablets.
PLASDONE S-630 copovidone is 60:40 copolymer of n-vinyl-2-pyrrolidone and vinylacetate.
The vinyl acetate in the polymer backbone lowers the polymer’s glass transition temperature compared with polyvinylpyrollidone (PVP) homopolymers and reduces hygroscopicity.
PLASDONE S-630 acts as an excellent tablet binder in dry granulation and direct compression tablet process.
PLASDONE S-630 is highly compressible and produces more flexible, less brittle films compared to films of PVP homopolymers.
PLASDONE S-630’s lower hygroscopicity improves stability in high humidity.
PLASDONE S-630 improves solubility and bioavailability of poorly soluble drug actives through formation of solid dispersions.
PLASDONE S-630 copovidone forms tough, clear, flexible films with high substantivity.
PLASDONE S-630 acts as a tablet binder resulting in tablets with high breaking force and low friability
PLASDONE S-630 is a binder in dry-granulations and direct compression processes.
PLASDONE S-630 is used in denture cleanser tablets
PLASDONE S-630 copovidone is a 60:40 random, linear copolymer produced by the free radical polymerization of N-vinyl-2-pyrollidone and vinyl acetate.
The pyrrolidone ring is responsible for excellent water solubility, adhesion, film forming and solubilization properties, while the vinyl acetate monomer reduces glass transition temperature (Tg) and hygroscopicity compared to homopolymers of pyrrolidone (PVP).
Well-known in the industry as a multipurpose excipient, copovidone functions as a binder, solubilizer/solid dispersion carrier and film former in a variety of pharmaceutical formulations
PLASDONE S-630 Ultra copovidone is a grade of PLASDONE S-630 designed to provide better performance in tablet formulations, hot melt extrusion (HME) and continuous processing by offering superior benefits compared to the original PLASDONE S-630 copovidone.
Features and Benefits of PLASDONE S-630:
PLASDONE S-630 Acts as a tablet binder resulting in denture cleanser tablets with high breaking force and low friability.
PLASDONE S-630 Forms tough, clear, flexible films with high substantivity to skin.
PLASDONE S-630 is Vegan suitable.
Properties of PLASDONE S-630:
Chemical Structure:
PLASDONE S-630 is a copolymer of polyvinylpyrrolidone (PVP) and vinyl acetate.
Physical Form:
PLASDONE S-630 is typically available in powder form.
Appearance:
The powder is usually white to off-white in color.
Solubility:
PLASDONE S-630 is soluble in water and many organic solvents.
Film-Forming:
PLASDONE S-630 has film-forming properties, making it suitable for coating applications.
Adhesive:
PLASDONE S-630 exhibits adhesive properties, which can be useful in various applications such as adhesives and coatings.
Tablet Binding:
PLASDONE S-630 acts as a binder in pharmaceutical formulations, helping to bind the ingredients of tablets together.
Disintegrant:
PLASDONE S-630 aids in the rapid disintegration of tablets upon contact with moisture, facilitating drug release and absorption.
Stability:
PLASDONE S-630 generally exhibits good stability under appropriate storage conditions.
Compatibility:
PLASDONE S-630 is compatible with a wide range of other pharmaceutical excipients and ingredients.
Handling and Storage of PLASDONE S-630:
Precautions for safe handling:
Avoid inhalation of vapour or mist.
Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510):
8A: Combustible, corrosive hazardous materials
Stability and Reactivity of PLASDONE S-630:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.
Disposal considerations:
Waste treatment methods:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product
First Aid Measures of PLASDONE S-630:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area.
If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.
In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.
If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.
Firefighting Measures of PLASDONE S-630:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture:
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas
Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental Release Measures of PLASDONE S-630:
Personal precautions, protective equipment and emergency procedures:
Use personal protective equipment.
Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.
Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.
Exposure Controls/Personal Protection of PLASDONE S-630:
Control parameters:
Components with workplace control parameters:
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.
Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove removal technique (without touching glove’s outer surface) to avoid skin contact with PLASDONE S-630.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
PLASDONE S-630 should not be construed as offering an approval for any specific use scenario.
Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.
If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.
Identifiers of PLASDONE S-630:
CAS Registry Number: 25086-89-9
EINECS Number: 500-987-8
NIST Chemistry WebBook ID: 25086-89-9
PubChem CID: 23673530
Specifications of PLASDONE S-630:
Appearance: White to off-white powder
Assay (as dry basis): ≥ 95%
Vinyl Acetate Content: ≤ 5%
Moisture Content: ≤ 5%
pH (5% aqueous solution): 3.0 – 7.0
Particle Size (D50): Typically around 25 – 50 µm
Solubility: Soluble in water and many organic solvents
Viscosity (5% aqueous solution): Typically around 4 – 8 mPa·s at 25°C
Bulk Density: Typically around 0.3 – 0.5 g/cm³