POLYOXYETHYLENE SORBITAN TRIOLEATE
POLYOXYETHYLENE SORBITAN TRIOLEATE
Polyoxyethylene sorbitan trioleate is a nonionic surfactant and emulsifier used in pharmaceuticals, cosmetics, and food products, recognized for its ability to stabilize emulsions and improve the solubility of hydrophobic substances.
In the pharmaceutical industry, Polyoxyethylene sorbitan trioleate enhances the bioavailability of hydrophobic drugs and stabilizes injectable formulations, vaccines, and protein-based therapeutics.
Polyoxyethylene sorbitan trioleate is biodegradable, making it an environmentally friendly choice for various industrial applications, while its low toxicity and regulatory approvals ensure its safety in food, cosmetics, and agricultural products.
CAS Number: 9005-70-3
EC Number: 618-422-4
Molecular Formula: CH4
Molecular Weight: 16.04246
Synonyms: Polysorbate 85, PEG-20 Sorbitan Trioleate, Sorbitan Trioleate Polyoxyethylene, Polyoxyethylene (20) Sorbitan Trioleate, Tween 85, Ethoxylated Sorbitan Trioleate, POE Sorbitan Trioleate, Polyethylene Glycol Sorbitan Trioleate, Sorbitan,tri-(9Z)-9-octadecenoate,poly(oxy-1,2-ethanediyl) derivs., Sorbitan,trioleate,polyoxyethylene derivs., Sorbitan,tri-9-octadecenoate,poly(oxy-1,2-ethanediyl) derivs.,(Z,Z,Z)-, TO 55, TO 65, Polysorbate 85, Tween 85, Poly(oxyethylene) sorbitan trioleate, Glycosperse TO 20, Sorbitan polyethoxy trioleate, Sorbimacrogol trioleate 300, Crill 12, Polyoxyethylene sorbitan trioleic acid ester, Emsorb 6903, Polyethylene glycol sorbitan trioleate, Sorbon T 85, Nikkol TO 30, Ethoxylated sorbitan trioleate, Montanox 85, Rheodol TW-O 320, Newcol 3-85, T-MAZ 85, Sorbax PTO 20, Rikemal O 852, Sorbitan trioleate polyoxyethylene ether, Crillet 45, Emsorb 6913, Witconol AL 69-66, Toximul SEE 340, Sinopol 3-85, Alkamuls T 85, Eumulgin STO 80, Aceporol 345T, Tween 85LM, Lonzest STO 20, Alkamuls T 85V, Pionin D 945T, Ecoteric T 85, Rheodol TW-O 320V, Agnique STO 20, Tego STO 85V, Disponil STO 20, Nikkol TO 30V, Alkamuls PSTO 20, T 85, Agnique STO 2095, Rheodol TW 0320V, Desmodur N 100-ethoxylated sorbitan trioleate copolymer, Montanox 85VG-DF, Newkalgen D 945T, Blaunon OT 320, TW 85, TO 30, 1340-86-9, 9015-60-5, 51367-06-7, 111389-05-0, 866916-41-8, 872017-39-5, 1630262-72-4, 85, Tween 85, Terpienol, FEMA 2917, Tween®TWEEN 80KR, Emsorb 903, emsorb6903, BASF PS 80, POLYSORBATE, Polyoxyethylene (20) Sorbitan Trioleate, Polyoxyethylene Sorbitan Trioleate, Polyoxyethylene Sorbitan Trioleate (20E.O.), Polysorbate 85 (INCI), Sorbimacrogol Trioleate 300, Sorbitan, Tri-9-Octadecenoate, Poly(Oxy-1,2-Ethanediyl) Derivs, Polyoxyethylene sorbitan trioleate, Alkest TW 85, Tween 85,
Polyoxyethylene sorbitan trioleate is a synthetic compound widely recognized for its role as a nonionic surfactant, emulsifier, and solubilizing agent across multiple industries.
Derived from the reaction of sorbitol, oleic acid, and ethylene oxide, Polyoxyethylene sorbitan trioleate features a hydrophilic polyoxyethylene chain and a lipophilic oleate ester group, enabling it to bridge the gap between water and oil phases effectively.
This dual functionality makes Polyoxyethylene sorbitan trioleate a key component in stabilizing emulsions and dispersions, ensuring the homogeneity and consistency of complex formulations.
In the pharmaceutical industry, polyoxyethylene sorbitan trioleate is employed to enhance the solubility and bioavailability of hydrophobic drugs, as well as to stabilize injectable formulations, vaccines, and protein-based therapeutics.
Polyoxyethylene sorbitan trioleate’s non-irritating and non-toxic properties make it particularly suitable for sensitive applications, including those involving parenteral administration.
In cosmetics and personal care products, such as creams, lotions, shampoos, and sunscreens, Polyoxyethylene sorbitan trioleate functions as an emulsifier and conditioning agent, promoting smooth textures and improving product spreadability.
In food processing, polyoxyethylene sorbitan trioleate serves as an emulsifier and stabilizer, helping to maintain the quality and appearance of processed foods such as sauces, dressings, baked goods, and frozen desserts.
Polyoxyethylene sorbitan trioleate prevents the separation of oil and water phases, thereby extending shelf life and ensuring consistent product performance.
Additionally, Polyoxyethylene sorbitan trioleate is used in dietary supplements to enhance the stability of lipid-based formulations.
Industrially, polyoxyethylene sorbitan trioleate finds applications in lubricants, textile treatments, coatings, and agrochemical formulations, where it facilitates the uniform dispersion of active ingredients.
Polyoxyethylene sorbitan trioleate is also used as a wetting and dispersing agent in paints and inks, improving their application properties.
Polyoxyethylene sorbitan trioleate’s resistance to extreme pH levels, temperature fluctuations, and oxidative conditions makes it a versatile and reliable additive in these demanding environments.
Despite its broad utility, polyoxyethylene sorbitan trioleate must be handled and formulated carefully, as excessive concentrations may lead to mild irritation or sensitization in some individuals.
Regulatory guidelines often specify maximum allowable concentrations for Polyoxyethylene sorbitan trioleate’s use in food, pharmaceuticals, and cosmetics to ensure safety.
Polyoxyethylene sorbitan trioleate’s biodegradability and low environmental impact further contribute to its appeal as a multifunctional ingredient in modern formulations.
Polyoxyethylene sorbitan trioleate is a nonionic emulsifier and surfactant and used in cosmetics and foods.
Polyoxyethylene sorbitan trioleate is a polyoxyethylene sorbitan trioleate non-ionic surfactant.
Polyoxyethylene sorbitan trioleate is a mixture of oleate esters of sorbitol and sorbitol anhydrides, consisting predominantly of the triester, condensed with approximately 20 moles of ethylene oxide.
Polyoxyethylene sorbitan trioleate can be used in agricultural products like fertilizers and plant growth regulators to help ensure that the active ingredients are uniformly dispersed and adhere to plant surfaces for better efficacy.
Polyoxyethylene sorbitan trioleate is employed in nanotechnology and drug delivery systems to help solubilize drugs and enhance their absorption, including in liposomal and micellar systems.
These delivery systems can target specific areas within the body, such as tumor sites, improving therapeutic outcomes.
Polyoxyethylene sorbitan trioleate is a non-ionic surfactant and emulsifier made by combining sorbitan (a sugar alcohol) with oleic acid (a fatty acid) and ethoxylating it with 20 moles of ethylene oxide.
Ungraded products supplied by Spectrum are indicative of a grade suitable for general industrial use or research purposes and typically are not suitable for human consumption or therapeutic use.
Polyoxyethylene sorbitan trioleate is part of the Polysorbate group, which includes several different sorbitan esters and ethylene oxide derivatives used in various industrial and consumer applications.
Polyoxyethylene sorbitan trioleate refers to the ethylene oxide (EO) groups attached to the sorbitan backbone.
In the case of Polyoxyethylene sorbitan trioleate, it specifically has 20 ethylene oxide units.
Polyoxyethylene sorbitan trioleate is formed when sorbitan is esterified with oleic acid (a monounsaturated fatty acid found in animal and vegetable fats).
Polyoxyethylene sorbitan trioleate has a relatively high HLB value (around 13-14), which means it is more effective as an emulsifier in formulations that require the blending of water and oil.
Polyoxyethylene sorbitan trioleate is generally considered to be safe when used in concentrations approved by regulatory authorities (such as the FDA for food and cosmetics).
However, in some individuals, Polyoxyethylene sorbitan trioleate may cause mild skin irritation or allergic reactions, especially in higher concentrations.
Polyoxyethylene sorbitan trioleate is not typically considered toxic or hazardous under normal conditions of use.
The HLB of Polyoxyethylene sorbitan trioleate is around 13–14, indicating its effectiveness as a highly hydrophilic emulsifier, which helps stabilize oil-in-water emulsions.
Polyoxyethylene sorbitan trioleate is first esterified with oleic acid (C18H34O2) to form sorbitan trioleate, a fatty acid ester.
The sorbitan ester is then subjected to ethoxylation, where it reacts with ethylene oxide (C2H4O) to form Polyoxyethylene (20) sorbitan trioleate.
The number 20 refers to the average number of ethylene oxide units attached to the sorbitan backbone.
Polyoxyethylene sorbitan trioleate is soluble in water and is also soluble in a variety of organic solvents such as alcohols, oils, and organic esters.
Polyoxyethylene sorbitan trioleate’s high solubility in water is a key feature that makes it effective for emulsifying a range of oil-based substances into water-based solutions.
Polyoxyethylene sorbitan trioleate is used in baked goods, confectioneries, and dairy products to ensure smooth texture, prevent ingredient separation, and improve mouthfeel.
Polyoxyethylene sorbitan trioleate enhances the dispersion of flavoring agents, colors, and emulsified fats in food products.
In topical formulations, Polyoxyethylene sorbitan trioleate can help in the delivery of poorly soluble drugs by enhancing their dissolution in the formulation, making it easier for the body to absorb the active pharmaceutical ingredients (APIs).
Helps to solubilize hydrophobic drug molecules and stabilizes emulsions or suspensions in injectable solutions.
In liquid pharmaceutical preparations, Polyoxyethylene sorbitan trioleate helps maintain a uniform distribution of the active drug, preventing it from settling or separating.
As an emulsifier in pesticide formulations, Polyoxyethylene sorbitan trioleate helps to improve the distribution and penetration of the pesticide into plant tissues.
In herbicides, Polyoxyethylene sorbitan trioleate aids in the mixing of oil-based active ingredients with water, improving the efficacy and coverage of the application.
In industrial formulations, Polyoxyethylene sorbitan trioleate is used as a stabilizer and dispersing agent, helping to maintain a consistent mix of pigments and solvents.
Polyoxyethylene sorbitan trioleate improves the emulsification of water and oils in lubricants, enhancing performance in industrial applications like cutting fluids and metalworking lubricants.
Polyoxyethylene sorbitan trioleate is used in textile processing to help emulsify oils and prevent the buildup of static electricity.
Enhances the emulsification of oils and greases, improving the cleaning action.
Polyoxyethylene sorbitan trioleate is used to break down dirt and grease, allowing for effective cleaning of surfaces while maintaining a smooth and non-abrasive formula.
Polyoxyethylene sorbitan trioleate is approved for use by several regulatory bodies worldwide.
Polyoxyethylene sorbitan trioleate is considered generally recognized as safe (GRAS) for use in food products, up to certain concentrations.
Polyoxyethylene sorbitan trioleate is approved for use in cosmetics and personal care products and is listed in the Cosmetic Ingredient Database (CosIng).
Polyoxyethylene sorbitan trioleate is also approved for use in pharmaceuticals and agricultural chemicals, subject to specific guidelines and concentration limits.
Polyoxyethylene sorbitan trioleate is biodegradable, which means it breaks down in the environment over time.
However, like many surfactants, Polyoxyethylene sorbitan trioleate can still contribute to water pollution if large amounts are released into water systems.
While typically not toxic in low concentrations, high concentrations of surfactants like Polyoxyethylene sorbitan trioleate can be toxic to aquatic organisms, affecting water quality and ecosystem balance.
Polyoxyethylene sorbitan trioleate can lower the surface tension of water, impacting the behavior of aquatic animals and plants.
Polyoxyethylene sorbitan trioleate is generally considered to have a low toxicity profile.
Polyoxyethylene sorbitan trioleate is typically produced through a process called ethoxylation.
This involves the addition of ethylene oxide molecules to a base molecule of sorbitan trioleate, which is derived from oleic acid (a fatty acid).
The process results in the formation of a polymer chain (ethylene oxide) that makes Polyoxyethylene sorbitan trioleate more hydrophilic (water-attracting), allowing it to function as a surfactant in emulsification processes.
The molecular formula for Polyoxyethylene sorbitan trioleate is C24H46O6, reflecting the combination of sorbitan, fatty acids (oleic acid), and polyoxyethylene groups (ethylene oxide polymers).
Polyoxyethylene sorbitan trioleate consists of sorbitan (a cyclic sorbitol ester) with three oleic acid molecules esterified at the hydroxyl positions, with a polyethylene glycol (PEG) group attached to the sorbitan molecule via ether linkages.
The “20” in the name refers to the average number of ethylene oxide units attached to the molecule.
The hydrophilic-lipophilic balance (HLB) of Polyoxyethylene sorbitan trioleate is typically around 15-16, which means it’s more hydrophilic and therefore suitable for forming oil-in-water emulsions.
One of the unique properties of Polyoxyethylene sorbitan trioleate is its ability to improve bioavailability by enhancing the solubility of poorly water-soluble drugs.
This is achieved by incorporating it into drug delivery systems like liposomes and micelles, which can help drugs cross biological membranes more effectively.
Polyoxyethylene sorbitan trioleate also allows for better absorption of active ingredients through the skin or mucosal membranes in topical or oral formulations.
Polyoxyethylene sorbitan trioleate is frequently used in injectable formulations of lipophilic drugs (drugs that are poorly soluble in water) due to its solubilizing properties.
Polyoxyethylene sorbitan trioleate ensures that such drugs are properly dissolved in the solution, making them easier to inject and ensuring more effective bioavailability once inside the body.
Polyoxyethylene sorbitan trioleate’s also used to prevent precipitation or crystallization of drugs during storage or transportation.
The surfactant helps maintain the drug in a dissolved state for extended periods, preventing clumping that can occur when the drug becomes less soluble.
In cosmetic and personal care products, Polyoxyethylene sorbitan trioleate plays a critical role in improving the long-term stability of emulsions. Emulsions are mixtures of oil and water, which are normally unstable and tend to separate over time.
Polyoxyethylene sorbitan trioleate ensures that the oils and water phases remain uniformly blended, giving products a smooth, consistent texture.
Polyoxyethylene sorbitan trioleate is often used in products like moisturizers, anti-aging creams, facial serums, and cleansers to help active ingredients such as vitamins (like Vitamin E), antioxidants, and hydroxy acids stay evenly distributed, enhancing their effectiveness on the skin.
Polyoxyethylene sorbitan trioleate can be found in conditioners and shampoos to improve the spreadability of conditioning agents, and to help reduce frizz by smoothing hair cuticles and improving the moisture balance.
Polyoxyethylene sorbitan trioleate is commonly used in various forms depending on the intended application:
Polyoxyethylene sorbitan trioleate can be used as a solubilizing agent for oral drugs, ensuring that the active ingredient is well-dissolved and absorbed by the body.
As an emulsifier in topical creams, Polyoxyethylene sorbitan trioleate stabilizes emulsions, allowing both water and oils to blend effectively without separating.
This is particularly important for moisturizing creams and sunscreens.
In injectables, Polyoxyethylene sorbitan trioleate helps to solubilize and stabilize compounds that are otherwise difficult to administer.
Polyoxyethylene sorbitan trioleate prevents the active pharmaceutical ingredients (APIs) from aggregating or crystallizing.
Polyoxyethylene sorbitan trioleate is also found in eye drops and ocular formulations where it stabilizes the formulation, ensuring even distribution of the active ingredients, which can improve absorption and sustained release.
Polyoxyethylene sorbitan trioleate is used in the formulation of biopharmaceuticals, especially recombinant proteins, vaccines, and gene therapies, where it helps stabilize protein structures and prevents aggregation or denaturation during storage and transportation.
In bioprocessing, Polyoxyethylene sorbitan trioleate can act as a non-ionic detergent, breaking up cell membranes and helping to solubilize membrane-bound proteins for extraction and analysis.
Polyoxyethylene sorbitan trioleate is commonly used in the preparation of nanoparticles, including liposomes and nanoemulsions, as it helps to stabilize these particles in a suspension and prevent coalescence.
This property is essential in drug delivery systems, where controlled release and targeted delivery are required.
Polyoxyethylene sorbitan trioleate’s also used in the development of liposomal drug formulations, where the surfactant helps stabilize the lipid bilayers, enhancing the bioavailability of poorly soluble drugs.
Polyoxyethylene sorbitan trioleate is used in various veterinary products, especially in injectable vaccines and oral medications for pets and livestock.
Polyoxyethylene sorbitan trioleate is used to improve the solubility and bioavailability of active ingredients, ensuring that the formulations are effective and safe for use in animals.
In anti-aging and moisturizing products, Polyoxyethylene sorbitan trioleate helps deliver active ingredients such as peptides, hyaluronic acid, and retinoids more effectively to the skin, improving their penetration and effectiveness.
Polyoxyethylene sorbitan trioleate is used in shampoos and conditioners to emulsify natural oils and butters (like argan oil, coconut oil) with water, leaving the hair moisturized without weighing it down.
Works in sunscreens and after-sun products to ensure even application of UV filters and improve the spreadability of sun protection agents across the skin.
Polyoxyethylene sorbitan trioleate is sometimes incorporated into wound care products (e.g., hydrogel dressings and surgical lubricants) to stabilize the gel structure and prevent drying out.
Polyoxyethylene sorbitan trioleate helps to maintain an optimal moist environment for wound healing.
In medical devices like catheters and surgical instruments, Polyoxyethylene sorbitan trioleate is used to improve the slip properties of lubricants, making procedures smoother and reducing friction.
Polyoxyethylene sorbitan trioleate can be found in fabric softeners, where it works to emulsify the various components (such as oils and conditioners) to improve the softening effect and reduce static electricity.
Polyoxyethylene sorbitan trioleate is a nonionic surfactant and emulsifier widely used in pharmaceuticals, cosmetics, food, and industrial applications.
Polyoxyethylene sorbitan trioleate is derived from the esterification of sorbitol and oleic acid, followed by ethoxylation, resulting in a viscous, yellow to amber liquid with excellent solubility in water, oils, and organic solvents.
Polyoxyethylene sorbitan trioleate is primarily utilized for its ability to stabilize emulsions, making it a critical ingredient in formulations such as creams, lotions, and pharmaceutical suspensions, where it ensures a uniform mixture of oil and water phases.
In the food industry, polyoxyethylene sorbitan trioleate serves as an emulsifier in products like salad dressings, sauces, and desserts, contributing to smooth textures and consistent quality.
Polyoxyethylene sorbitan trioleate is also a key component in industrial applications, such as in the production of lubricants, textile treatments, and coatings, where it facilitates the blending of disparate substances.
Known for its mild nature and low toxicity, polyoxyethylene sorbitan trioleate is generally regarded as safe for use in regulated concentrations, though care should be taken to avoid exceeding recommended limits, as high levels may cause irritation.
Polyoxyethylene sorbitan trioleate’s versatility and stability under a wide range of temperatures and pH levels make it a highly valuable additive across diverse industries.
Uses of Polyoxyethylene Sorbitan Trioleate:
Polyoxyethylene sorbitan trioleate is an emulsifier produced by reacting oleic acid with sorbitol to yield a product which is reacted with ethylene oxide.
Polyoxyethylene sorbitan trioleate is a nonionic, water-dispersible surface-active agent that is very soluble in water.
Polyoxyethylene sorbitan trioleate is also termed polysorbate 80.
Polyoxyethylene sorbitan trioleate is used in ice cream and frozen desserts for overrun and dryness; as a disperser of flavors and colors in pickles; and for volume and texture in baked goods.
Polyoxyethylene sorbitan trioleate is frequently used with monoand diglycerides at usage levels ranging from 0.05 to 0.10%.
Polyoxyethylene sorbitan trioleate has been used in a study to assess the potential application of niosomes for the delivery of ammonium glycyrrhizinate for the treatment of inflammatory diseases.
Polyoxyethylene sorbitan trioleate is a mid-range HLB, nonionic surfactant suggested for use in textile chemicals (lubricant, emulsifier), household products (o/w emulsifier) and cosmetic formulations (o/w emulsifier).
As an emulsifier in processed foods to blend ingredients that normally do not mix well, such as oils and water.
Polyoxyethylene sorbitan trioleate is used in items like ice cream, margarine, and salad dressings.
Polyoxyethylene sorbitan trioleate is used in creams, lotions, shampoos, and conditioners to help mix oil-based and water-based ingredients, enhancing texture and stability.
Polyoxyethylene sorbitan trioleate acts as a solubilizer for essential oils and fragrances in products like perfumes and body sprays.
Employed in the formulation of injectables, topical creams, and oral suspensions where it helps to solubilize active pharmaceutical ingredients (APIs) that are poorly water-soluble, improving their bioavailability.
Polyoxyethylene sorbitan trioleate is used as a stabilizer in formulations containing both water and oil phases.
Found in agricultural chemicals, such as pesticides, herbicides, and fungicides, to help emulsify the active ingredients, ensuring they are more effectively spread on plant surfaces.
Polyoxyethylene sorbitan trioleate is used in lubricants and polishes, especially in products requiring emulsification of oils and water to improve smoothness, stability, and performance.
Included in detergents, floor cleaners, and dishwashing liquids for emulsifying oils, greases, and other hydrophobic substances, enhancing cleaning power.
Polyoxyethylene sorbitan trioleate is used to improve the solubility and bioavailability of lipophilic (poorly water-soluble) drugs, particularly in injectable formulations.
Polyoxyethylene sorbitan trioleate helps in the dissolution and stabilization of active pharmaceutical ingredients (APIs) in liquid formulations.
Polyoxyethylene sorbitan trioleate is commonly used in the formulation of injectable drugs, including vaccines and intravenous (IV) fluids, to stabilize emulsions and prevent precipitation of drug substances.
Polyoxyethylene sorbitan trioleate is used in topical formulations, it helps emulsify oil and water phases, providing a smooth and consistent texture for creams, lotions, and ointments.
Polyoxyethylene sorbitan trioleate is widely used in cosmetic products like moisturizers, sunscreens, and anti-aging creams to ensure that water and oil components remain mixed and stable over time.
Polyoxyethylene sorbitan trioleate helps in creating stable emulsions in shampoos, conditioners, and other hair care products, improving the uniform distribution of active ingredients.
Polyoxyethylene sorbitan trioleate helps in dissolving oils and removing dirt from the skin without irritating, making it a common ingredient in makeup removers and cleansing wipes.
Polyoxyethylene sorbitan trioleate stabilizes the active ingredients in deodorants and antiperspirants, ensuring they are effective and evenly distributed.
In food products, Polyoxyethylene sorbitan trioleate functions as an emulsifier to combine water and oil components, improving the texture and stability of dressings, mayonnaise, and ice cream.
Polyoxyethylene sorbitan trioleate is used in bakery products, beverages, and confectioneries to help prevent separation and improve product consistency.
Polyoxyethylene sorbitan trioleate is used in the formulation of pesticides, helping to emulsify and evenly distribute the active ingredients across plant surfaces, ensuring better absorption and effectiveness.
In gene therapy research, Polyoxyethylene sorbitan trioleate is used to facilitate the delivery of therapeutic genes to target cells by enhancing the solubility and stability of gene delivery vectors.
Polyoxyethylene sorbitan trioleate is used in cleaning products like detergents to help dissolve oils and dirt and improve cleaning efficiency.
Polyoxyethylene sorbitan trioleate can act as an emulsifier in the formulation of paints, inks, and coatings, improving the distribution of pigments and other ingredients.
In veterinary formulations, Polyoxyethylene sorbitan trioleate is used as an emulsifier and solubilizer for drugs, particularly in injectable or topical medications for animals.
Polyoxyethylene sorbitan trioleate can be used in environmental applications to aid in the breakdown and removal of contaminants in soil and water by improving the solubility and dispersion of remediation agents.
Polyoxyethylene sorbitan trioleate is used as an emulsifier, solubilizer, stabilizer, diffusant, lubricant, etc.
Polyoxyethylene sorbitan trioleate is used in cosmetics and foods.
Polyoxyethylene sorbitan trioleate is frequently used with monoand diglycerides at usage levels ranging from 0.05%~0.10%.
Polyoxyethylene sorbitan trioleate is a liquid ethoxylated sorbitan triester derived from natural fatty acid (oleic acid).
Polyoxyethylene sorbitan trioleate functions as an emulsifier and wetting agent, primarily used in hygiene nonwovens.
Polyoxyethylene sorbitan trioleate is in liquid form and has an HLB value of 11.0.
Polyoxyethylene sorbitan trioleate meets sustainability criteria as it is majority bio-based (95-50%) and offers an RSPO grade option.
Additionally, Polyoxyethylene sorbitan trioleate is certified as halal and recognized as a safer choice.
Polyoxyethylene sorbitan trioleate is an amber oily, viscose liquid.
Polyoxyethylene sorbitan trioleate is non-toxic and odorless.
The relative density of Polyoxyethylene sorbitan trioleate is 1.00~1.05, and the HLB value is 11.0.
Polyoxyethylene sorbitan trioleate is soluble in water, dilute acid/alkalis, and most organic solvents and insoluble in acetone and polyethylene glycol.
And Polyoxyethylene sorbitan trioleate can disperse in water.
In crude oil production, Polyoxyethylene sorbitan trioleate acts as an emulsifier and paraffin inhibitor.
Polyoxyethylene sorbitan trioleate, consists of sorbitol, ethylene oxide, and oleic acid.
Polyoxyethylene sorbitan trioleate is stored in a cool, dry, and draughty place.
The shelf life of Polyoxyethylene sorbitan trioleate is two years.
Then, Polyoxyethylene sorbitan trioleate can still be used if qualified after re-check.
Polyoxyethylene sorbitan trioleate is a non-ionic emulsifier.
Polyoxyethylene sorbitan trioleate is European Kosher, RSPO, Halal, ISO 9001:2015 and Feed Chain Alliance certified.
Polyoxyethylene sorbitan trioleate is a light yellow to amber oily viscose liquid, non-toxic, easily soluble in water, soluble in ethanol, vegetable oil, ethyl acetate, methanol, insoluble in mineral oil.
HLB value of Polyoxyethylene sorbitan trioleate is 15.0
Polyoxyethylene sorbitan trioleate is a non-ionic surfactant derived from sorbitan monooleate.
Polyoxyethylene sorbitan trioleate’s a yellowish, viscous liquid widely used for its emulsifying, solubilizing, and stabilizing properties.
Polyoxyethylene sorbitan trioleate is a mixture of oleate esters of sorbitol and sorbitol anhydrides, consisting predominantly of the triester, condensed with approximately 20 moles of ethylene oxide.
Polyoxyethylene sorbitan trioleate is used as an emulsifier, solubilizer, stabilizer, diffusant, lubricant, etc.
Polyoxyethylene sorbitan trioleate is used in cosmetics and foods.
Polyoxyethylene sorbitan trioleate emulsifier is used in ice cream and frozen desserts for overrun and dryness, as a disperser of flavors and colors in pickles, and for volume and texture in baked goods.
Polyoxyethylene sorbitan trioleate is frequently used with monoand diglycerides at usage levels ranging from 0.05%~0.10%.
Polyoxyethylene sorbitan trioleate has been used in a study to assess the potential application of niosomes for delivering ammonium glycyrrhizinate to treat inflammatory diseases.
Polyoxyethylene sorbitan trioleate has also been used in a study to investigate the joint action of antifouling substances in copper-free paints.
Polyoxyethylene sorbitan trioleate is a mid-range HLB, nonionic surfactant suggested for use in textile chemicals (lubricant, emulsifier), household products (o/w emulsifier) and cosmetic formulations (o/w emulsifier).
Polyoxyethylene sorbitan trioleate is used in cosmetics.
Polyoxyethylene sorbitan trioleate is soluble in water, methanol and ethanol, insoluble in mineral oil, used as emulsifier, dispersant, wetting agent, solubilizer and stabilizer.
Polyoxyethylene sorbitan trioleate is used as stabilizer and foaming agent in the production of polyurethane foam plastics;
Polyoxyethylene sorbitan trioleate can be used as antistatic agent in synthetic fiber, and is the intermediate of chemical fiber oil agent;
Polyoxyethylene sorbitan trioleate is used as wetting agent and dispersing agent in photographic film making;
In the process of fabric waterproof to emulsify silicone oil, Polyoxyethylene sorbitan trioleate has a good effect, also used in nylon and viscose cord as oil agent and water-soluble emulsifier, often mixed with S-80.
Polyoxyethylene sorbitan trioleate is used as oil field emulsifier, paraffin inhibitor, heavy oil wetting agent, drag reduction agent and near-well zone treatment agent.
Polyoxyethylene sorbitan trioleate is used as the lubricating coolant for precision machine tools.
End Uses:
Furniture Polishes, Industrial Cleaners, Institutional Cleaners, Kitchen Wipes, Multipurpose Surface Cleaners, Multisurface Cleaners, Multisurface Polishes, Polishes, Shoe Polishes
Food Additive:
Polyoxyethylene sorbitan trioleate stabilizes and emulsifies fat-based systems in confectionery and baked goods.
Cosmetic Industry:
Polyoxyethylene sorbitan trioleate is used in creams, lotions, and hair products as an emulsifier and solubilizer.
Pharmaceuticals:
Polyoxyethylene sorbitan trioleate helps in stabilizing emulsions and suspensions in drug formulations.
Industrial Applications:
Polyoxyethylene sorbitan trioleate is used as an emulsifier in oil-in-water systems for enhanced stability.
Functions of Polyoxyethylene Sorbitan Trioleate:
Emulsifier,
Wetting Agent
Benefits of Polyoxyethylene Sorbitan Trioleate:
Polyoxyethylene sorbitan trioleate ensures stable and uniform emulsions in food, cosmetics, and pharmaceutical products.
Polyoxyethylene sorbitan trioleate improves texture and sensory qualities in personal care products.
Polyoxyethylene sorbitan trioleate prolongs the shelf life of emulsified systems.
Safe for use in various regulated applications.
Properties of Polyoxyethylene Sorbitan Trioleate:
Polyoxyethylene sorbitan trioleate is particularly useful in formulations requiring a higher HLB surfactant:
Emulsifier:
Polyoxyethylene sorbitan trioleate creates stable emulsions between oil and water phases.
Solubilizer:
Polyoxyethylene sorbitan trioleate improves the solubility of hydrophobic substances in water-based products.
Stabilizer:
Polyoxyethylene sorbitan trioleate prevents phase separation in emulsions and suspensions.
Detergent:
Polyoxyethylene sorbitan trioleate acts as a surfactant in cleaning products.
Food industry:
Polyoxyethylene sorbitan trioleate is used as an emulsifier, stabilizer, and wetting agent.
Pharmaceuticals:
Polyoxyethylene sorbitan trioleate is employed as a solubilizer, emulsifier, and stabilizer in drug formulations.
Cosmetics:
Polyoxyethylene sorbitan trioleate is used in various cosmetic products, including creams, lotions, and shampoos.
Other Properties:
Non-ionic surfactant providing effective emulsification and stabilization properties.
Resistant to acidic and alkaline environments.
Compatible with a wide range of oils, surfactants, and other ingredients.
Manufacturing Methods of Polyoxyethylene Sorbitan Trioleate:
After preheating 1 mol disk 80, put it into the reaction kettle, add a sodium hydroxide aqueous solution of catalyst amount under stirring, start stirring, and vacuum dehydration.
After replacing the air in the kettle with nitrogen, the temperature was raised to 140°C and 22 mol of ethylene oxide was started.
The reaction temperature was maintained at 180 to 190°C.
After the ethylene oxide was passed, the evacuation was stopped.
After cooling, the material liquid is poured into a neutralization kettle and neutralized with acetic acid to about acid value 2, then decolorized with an appropriate amount of hydrogen peroxide, and finally dehydrated to a moisture content of 3%, and the finished product, Polyoxyethylene sorbitan trioleate, is obtained by cooling and discharging the packaging.
Production of Polyoxyethylene Sorbitan Trioleate:
Polyoxyethylene sorbitan trioleate is produced through a multi-step chemical process involving esterification and ethoxylation.
The process begins with sorbitol, derived from plant-based starches, which is dehydrated to form sorbitan.
Sorbitan then reacts with oleic acid, a fatty acid sourced from plant oils, to produce sorbitan trioleate through an esterification reaction catalyzed by acids under controlled heat.
In the next step, ethylene oxide is added to the sorbitan trioleate in a pressurized reactor at elevated temperatures, introducing polyoxyethylene chains in a process called ethoxylation.
The number of ethylene oxide units added is carefully controlled to achieve the desired hydrophilic-lipophilic balance (HLB), crucial for its functionality as an emulsifier.
After ethoxylation, Polyoxyethylene sorbitan trioleate undergoes purification to remove residual catalysts, byproducts, and unreacted components, followed by vacuum drying to ensure stability.
The final product is subjected to rigorous quality control to confirm purity, HLB value, and emulsification performance before being packaged and stored under conditions that protect it from temperature extremes and moisture.
Occurence of Polyoxyethylene Sorbitan Trioleate:
Polyoxyethylene sorbitan trioleate is a synthetic compound and does not occur naturally.
Polyoxyethylene sorbitan trioleate is specifically engineered for industrial and commercial applications through chemical synthesis.
The raw materials used in Polyoxyethylene sorbitan trioleate’s production, such as sorbitol and oleic acid, are derived from naturally occurring sources like plant-based starches and oils, making its origin partially rooted in nature.
However, Polyoxyethylene sorbitan trioleate itself is the result of advanced chemical processes, including esterification and ethoxylation, that do not naturally occur.
Consequently, Polyoxyethylene sorbitan trioleate is a fully synthetic emulsifier and surfactant designed for use in pharmaceuticals, food, cosmetics, and industrial applications.
History of Polyoxyethylene Sorbitan Trioleate:
The history of polyoxyethylene sorbitan trioleate is closely tied to advancements in synthetic chemistry and the growing need for emulsifiers in industrial and commercial applications.
Polyoxyethylene sorbitan trioleate’s development can be traced back to the mid-20th century when chemists sought to create versatile surfactants capable of stabilizing emulsions in food, pharmaceutical, and cosmetic products.
The ethoxylation process, which involves reacting compounds with ethylene oxide to improve water solubility, was a pivotal innovation that enabled the creation of polysorbates, including Polyoxyethylene sorbitan trioleate.
Derived from sorbitol (a sugar alcohol) and oleic acid (a fatty acid found in plant oils), polysorbates offered a blend of hydrophilic and lipophilic properties, making them ideal emulsifiers.
Polysorbates, including Polyoxyethylene sorbitan trioleate, gained widespread adoption in the 1950s and 1960s as industries expanded their product lines to meet consumer demands.
In food, they were used to improve the texture and shelf life of processed products.
In pharmaceuticals and cosmetics, polysorbates were prized for their ability to stabilize formulations and enhance the solubility of active ingredients.
Today, Polyoxyethylene sorbitan trioleate remains an essential ingredient in various applications, with its production refined to meet modern safety and environmental standards.
Polyoxyethylene sorbitan trioleate’s development represents a milestone in applied chemistry, reflecting the intersection of innovation and practical utility.
Handling and Storage of Polyoxyethylene Sorbitan Trioleate:
Handling:
Handle in accordance with standard industrial hygiene practices.
Avoid contact with skin, eyes, and clothing.
Use appropriate personal protective equipment (PPE) such as gloves, goggles, and protective clothing to prevent exposure.
Avoid inhaling fumes or mist.
Wash hands thoroughly after handling.
Avoid food, drink, or smoking in areas where the substance is handled.
Storage:
Store in a cool, dry, well-ventilated area.
Protect from direct sunlight and high heat sources to maintain stability.
Store in tightly sealed containers made of compatible materials like HDPE or stainless steel.
Keep the container closed when not in use.
Ideal storage temperature is between 15°C to 30°C (59°F to 86°F).
Do not store near oxidizing agents.
Shelf Life:
Under proper storage conditions, Polyoxyethylene Sorbitan Trioleate has a shelf life of up to 24 months.
Reactivity and Stability of Polyoxyethylene Sorbitan Trioleate:
Stability:
Polyoxyethylene Sorbitan Trioleate is stable under normal handling and storage conditions.
Polyoxyethylene sorbitan trioleate is non-reactive in typical industrial environments.
Reactivity:
Polyoxyethylene sorbitan trioleate is generally inert but may undergo reactions in extreme conditions, such as:
Reaction with strong oxidizing agents, which could cause degradation.
Potential degradation at very high temperatures or in the presence of strong acids.
Hazardous Decomposition Products:
When heated to decomposition, may release toxic fumes including carbon monoxide, carbon dioxide, and nitrogen oxides.
Conditions to Avoid:
High temperatures.
Exposure to direct sunlight for prolonged periods.
Contact with incompatible materials (strong acids or oxidizers).
First Aid Measures of Polyoxyethylene Sorbitan Trioleate:
Inhalation:
May cause respiratory irritation if inhaled.
Remove affected person to fresh air immediately.
If symptoms persist, seek medical attention.
Skin Contact:
Prolonged contact may cause mild skin irritation.
Wash affected area with soap and water.
Remove contaminated clothing.
If irritation persists, seek medical attention.
Eye Contact:
May cause mild irritation to the eyes.
Flush eyes with water for at least 15 minutes, holding eyelids open.
Seek medical attention if irritation persists.
Ingestion:
May cause mild gastrointestinal discomfort if ingested.
Do not induce vomiting.
Rinse mouth with water and give plenty of water to drink.
Seek medical attention if large amounts are ingested.
Firefighting Measures of Polyoxyethylene Sorbitan Trioleate:
Suitable Extinguishing Media:
Use water spray, foam, dry chemical powder, or carbon dioxide (CO₂) for extinguishing fires.
Firefighting Procedures:
Firefighters should wear self-contained breathing apparatus (SCBA) and full protective clothing.
If the substance is involved in a fire, use water spray to cool containers and prevent rupture.
Fire and Explosion Hazards:
Combustible material.
May produce hazardous decomposition products, including carbon monoxide and carbon dioxide.
Accidental Release Measures of Polyoxyethylene Sorbitan Trioleate:
Personal Precautions:
Ensure proper ventilation.
Wear appropriate PPE, including gloves, goggles, and protective clothing.
Environmental Precautions:
Avoid releasing into the environment.
Prevent contamination of water sources, drains, or soil.
Cleanup Procedures:
Absorb spill with inert materials such as sand, earth, or vermiculite.
Sweep up and place in an appropriate container for disposal.
Ensure the area is well-ventilated during cleanup.
Dispose of in accordance with local, regional, and national regulations.
Exposure Controls/Personal Protective Equipment of Polyoxyethylene Sorbitan Trioleate:
Exposure Limits:
There are no established occupational exposure limits for Polyoxyethylene Sorbitan Trioleate.
Engineering Controls:
Ventilation:
Provide adequate ventilation to maintain air quality and reduce the risk of inhalation exposure.
Use local exhaust ventilation in high-use areas.
Personal Protective Equipment (PPE):
Respiratory Protection:
Use NIOSH-approved respirators if the workplace atmosphere exceeds acceptable limits or if Polyoxyethylene sorbitan trioleate is processed in a form that could create dust or mist.
Hand Protection:
Wear chemical-resistant gloves made of materials such as nitrile or neoprene.
Eye Protection:
Use safety goggles or face shields to prevent eye contact.
Skin Protection:
Wear protective clothing such as aprons or lab coats to avoid skin contact.
Additional Recommendations:
Follow good industrial hygiene practices.
Provide eyewash stations and safety showers in case of accidental exposure.
Identifiers of Polyoxyethylene Sorbitan Trioleate:
IUPAC Name: Poly(oxyethylene) sorbitan trioleate
Chemical Formula: C100H188O28
CAS Number:9005-70-3
Molecular Weight: Approximately 1500 g/mol
UNII: 331ISU53W5
E Number: E436
EC Number: 500-019-9
CAS Number: 9005-70-3
Molecular Weight: Approx. 1500 g/mol
UNII: 331ISU53W5
E Number: E436
Chemical Class: Nonionic surfactant and emulsifier
CAS Number: 9005-70-3
Molecular Formula: CH4
Molecular Weight: 16.04246
EINECS Number: 618-422-4
CAS Number: 9005-70-3
EC Number: 500-022-5
Molecular Formula: C100H188O28
Properties of Polyoxyethylene Sorbitan Trioleate:
Melting point: -20 °C
Boiling point: 100 °C
Density: 1.028 g/mL at 20 °C
vapor pressure: <1 mm Hg ( 20 °C) refractive index: n20/D 1.473 Flash point: >230 °F
storage temp.: Store below +30°C.
solubility: Dispersible in water, in anhydrous ethanol, in ethyl acetate and in methanol, practically insoluble in fatty oils and in liquid paraffin.
form: viscous liquid
Specific Gravity: 1.030 (20/4℃)
color: Light yellow to Brown
EC Number: 500-022-5
CAS Number: 9005-70-3
Molecular Formula: C100H188O28
Molecular Weight: Approximately 1462 g/mol
Appearance: Amber viscous liquid or paste
Density: ~1.05 g/cm³ at 25°C
Solubility: Soluble in water and ethanol; forms stable emulsions
Melting Point: Liquid or semi-solid at room temperature
Boiling Point: Decomposes before boiling
Flash Point: >149°C (300°F)
Hydrophilic-Lipophilic Balance (HLB): 11.0
Melting point: -20 °C
Boiling point: 100 °C
Density: 1.028 g/mL at 20 °C
vapor pressure: <1 mm Hg ( 20 °C) refractive index: n20/D 1.473 Flash point: >230 °F
storage temp.: Store below +30°C.
solubility: Dispersible in water, in anhydrous ethanol, in ethyl acetate and in methanol, practically insoluble in fatty oils and in liquid paraffin.
form: viscous liquid
Specific Gravity: 1.030 (20/4℃)
color: Light yellow to Brown
Appearance: Amber or pale yellow, viscous liquid.
Odor: Mild, characteristic odor.
Taste: Bland and slightly oily (when used in food-grade applications).
Density: ~1.05–1.10 g/cm³ (at 20°C).
Viscosity: Highly viscous at room temperature; viscosity decreases with increasing temperature.
Melting Point: Not applicable; remains in liquid form at room temperature.
Boiling Point: Decomposes before boiling.
Specifications of Polyoxyethylene Sorbitan Trioleate:
Appearance: Amber to pale yellow, viscous liquid.
Odor: Mild and characteristic.
Acid Value: ≤ 2.0 mg KOH/g
Saponification Value: 45–55 mg KOH/g
Hydroxyl Value: 65–80 mg KOH/g
Moisture Content: ≤ 3.0%
Names of Polyoxyethylene Sorbitan Trioleate:
Regulatory process names:
Emsorb 6903
Glycosperse TO-20
Liposorb TO-20
polyethyleneglycol sorbitan trioleate
Polyoxyethylene (20) sorbitan trioleate
Polyoxyethylene sorbitan trioleate
Polysorbate 85
Protasorb TO-20
Sorbimacrogol trioleate 300
Sorbitan, tri-(9Z)-9-octadecenoate, poly(oxy-1,2-ethanediyl) derivs.
Sorbitan, tri-9-octadecenoate, poly(oxy-1,2-ethanediyl) derivs.
Sorbitan, trioleate polyoxyethylene deriv.
Tween 85
IUPAC names:
Ethoxylates
methyl 3-(1,3-benzodioxol-5-ylmethylsulfamoyl)thiophene-2-carboxylate
Polyethylene glycol sorbitan trioleate
Polyethyleneglycol sorbitan trioleate
POLYOXYETHYLENE SORBITAN TRIOLEATE
Polyoxyethylene sorbitan trioleate
Polyoxyethylene sorbitan trioleate
Polysorbate 85
Sorbitan, tri-9-octadecenoate, poly(oxy-1,2-ethanediyl) deri vs., (Z,Z,Z)-
Sorbitan, trioleate, ethoxylated
Other names:
Polyethylene glycol sorbitan trioleate
Polyoxyethylene Sorbitan Trioleate
Other identifiers:
111389-05-0
1340-86-9
51367-06-7
872017-39-5
9005-70-3