TRICALCIUM CITRATE
TRICALCIUM CITRATE
Tricalcium citrate, a calcium salt of citric acid with the chemical formula Ca3(C6H5O7)2, is a widely used compound in the food, pharmaceutical, and health industries, known for its high calcium bioavailability and suitability for fortifying products.
Tricalcium citrate’s neutral taste profile, non-toxic nature, and stability under various pH conditions make it a preferred choice for diverse formulations, including food, dietary supplements, and pharmaceutical applications.
With its high calcium content of 21% and better bioavailability compared to inorganic calcium sources, tricalcium citrate is an economical and effective ingredient for addressing nutritional deficiencies.
CAS number: 5785-44-4
EC number: 212-391-7
Molecular Formula: Ca3(C6H5O7)2
Molar Mass: 498.46 g/mol
Synonyms: Calcium citrate, 813-94-5, Tricalcium dicitrate, Acicontral, TRICALCIUM CITRATE, Calcitrate, Citracal, Citrical, Calcium citrate, tribasic, Tribasic calcium citrate, Calcium citrate [USAN], Calcium Citrate anhydrous, HSDB 5756, Citric acid, calcium salt (2:3), EINECS 212-391-7, Calcium 2-hydroxy-1,2,3-propanetricarboxylate (3:2), tricalcium citrate tetrahydrate, INS NO.333(III), UNII-86117BWO7P, INS-333(III), 2-Hydroxy-1,2,3-propanetricarboxylic acid calcium salt (2:3), 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, calcium salt (2:3), 86117BWO7P, E-333(III), tricalcium;2-hydroxypropane-1,2,3-tricarboxylate, Calcimax, EC 212-391-7, 7693-13-2, Calcium (as citrate), calcium 2-hydroxypropane-1,2,3-tricarboxylate (3:2), calciumcitrate, Lime citrate, 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, calcium salt, Calcium Citrate Powder, calcium citrate tribasic, Calcium Citrate USP, FCC, tricalcium bis(citric acid), CALCIUM CITRATE [MI], CALCIUM CITRATE [HSDB], C6H8O7.3/2Ca, CHEMBL2106123, DTXSID7061148, CALCIUM CITRATE [WHO-DD], citric acid calcium salt (2:3), CHEBI:190513, FNAQSUUGMSOBHW-UHFFFAOYSA-H, C6-H8-O7.3/2Ca, AKOS015839590, DB11093, Calcium Citrate Malate Glycinate 21% 40M, LS-180488, Q420280, Calcium Citrate Malate Carbonate 23%, Coarse Granu, J-509604, calcium 2-hydroxypropane-1,2,3-tricarboxylate (3/2), tricalcium bis(2-hydroxypropane-1,2,3-tricarboxylic acid), 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, calcium salt, hydrate (2:3:2) , Calcium 2-hydroxy-1,2,3-propanetricarboxylate hydrate (3:2:4) , Calcium 2-hydroxypropane-1,2,3-tricarboxylate hydrate (3:2:4), Calcium Citrate (Tricalcium citrate):1,2,3-Propanetricarboxylicacid, 2-hydroxy-, calcium salt (2:3), tetrahydrate, Calcium-2-hydroxy-1,2,3-propantricarboxylathydrat (3:2:4), Citrate de calcium, hydrate (2:3:4), 212-391-7, 2-hydroxypropane-1,2,3-tricarboxylate, 5785-44-4, Calcium 2-hydroxypropane-1,2,3-tricarboxylate tetrahydrate
Tricalcium citrate, a calcium salt of citric acid with the chemical formula Ca3(C6H5O7)2, is a widely used compound in the food, pharmaceutical, and health industries.
Known for its high calcium bioavailability, Tricalcium citrate is an essential ingredient in products designed to fortify calcium levels, particularly in populations where calcium deficiencies are prevalent.
Tricalcium citrate appears as a fine, white, odorless powder that is slightly soluble in water and minimally soluble in alcohol, making it suitable for various applications.
In the food industry, tricalcium citrate functions as a stabilizer, sequestrant, and acidity regulator, ensuring the structural integrity and consistency of products such as dairy goods, baked items, beverages, and processed foods.
Tricalcium citrate’s neutral taste profile and non-toxic nature make it a preferred choice for calcium enrichment without altering the sensory properties of food.
In the pharmaceutical sector, tricalcium citrate is commonly used in calcium supplements and formulations aimed at promoting bone health and preventing conditions like osteoporosis and hypocalcemia.
Tricalcium citrate is particularly beneficial for individuals who have difficulty absorbing calcium from traditional sources, such as those with lactose intolerance or vegan diets.
Additionally, Tricalcium citrate’s role extends to enhancing bone density, supporting muscle function, and contributing to overall metabolic processes requiring calcium ions.
Beyond its functional benefits, tricalcium citrate’s versatility in compatibility with diverse formulations makes it a highly adaptable compound.
Tricalcium citrate’s stability under various pH conditions and ability to integrate seamlessly into powdered, liquid, or tablet forms ensure its widespread usage.
Tricalcium citrate has also found applications in specialized dietary products targeted at children, the elderly, and pregnant women, addressing specific nutritional requirements.
Tricalcium citrate is lauded for its safety profile, regulatory approvals across major markets, and contribution to addressing global nutritional deficiencies, making it an indispensable ingredient in health and wellness industries.
The most commonly used calcium salt of citric acid is tricalcium dicitrate tetrahydrate, hereinafter referred to as tricalcium citrate.
In some countries such as USA, tricalcium citrate is simply denominated calcium citrate.
Tricalcium citrate is produced by complete neutralisation of citric acid with a high purity calcium source such as calcium hydroxide or calcium carbonate.
With its high calcium content of 21%, tricalcium citrate is the most economic calcium salt among the commonly used organic calcium salts.
Tricalcium citrate is supplied as a white, odourless, crystalline powder or fine powder.
Tricalcium citrate is slightly soluble in water and freely soluble in diluted hydrochloric acid.
In contrary to other salts, tricalcium citrate is better soluble at lower temperatures (so-called “inverse solubility”).
Tricalcium citrate is practically insoluble in alcohol.
During heat treatment, Tricalcium citrate is less reactive than other calcium salts due to its inverse solubility.
With regard to its significantly better bioavailability, tricalcium citrate is preferred over inorganic calcium sources such as calcium carbonate or calcium phosphate.
Tricalcium citrate is used for citric acid and to make other citrates and improve the baking of flour;
Tricalcium citrate is also used as nutrient content, food ingredient (sequestrant and astringent agent) and medicine.
Tricalcium citrate was characterized as a tableting excipient for direct compression (DC) and dry granulation (DG).
The most commonly used calcium salt of citric acid is tricalcium dicitrate tetrahydrate, hereinafter referred to as tricalcium citrate.
Produced by complete neutralization of citric acid with a high purity calcium source such as calcium hydroxide or calcium carbonate.
Tricalcium citrate is used as a cleaning agent in dentifrices.
Tricalcium citrate are typically sold in the form of calcium carbonate or calcium citrate.
Tricalcium citrate is a calcium salt that’s easier to absorb but less potent than calcium carbonate.
You may need to take more calcium citrate pills in order to achieve your desired dosage.
For anyone who takes heartburn medication or has digestive issues, Tricalcium citrate is often the better choice, since stomach acid isn’t required for absorption.
Tricalcium citratee is safe for most people when not taken in excess of 2,500 milligrams per day.
Tricalcium citrate’s available over the counter and typically recommended in multiple doses (of 500 milligrams or less) that add up to 1,200 to 1,500 milligrams a day.
Tricalcium citrate can be taken on a full or empty stomach at any time of the day.
Tricalcium citrate has the chemical formula of Na3C6H5O7.
Tricalcium citrate is sometimes referred to simply as “sodium citrate”, though sodium citrate can refer to any of the three sodium salts of citric acid.
Tricalcium citrate possesses a saline, mildly tart flavor, and is a mild alkali.
Tricalcium citrate may be used to treat conditions caused by low calcium levels such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany).
Tricalcium citrate is a tricalcium citrate tetrahydrate designed to function as a direct compression excipient.
Tricalcium citrate combines exceptional compression characteristics, good flowability and good tolerability.
Tricalcium citrate is a tricalcium citrate tetrahydrate designed to function as filler or diluent.
Tricalcium citrate is suitable for usage in direct compression.
Tricalcium citrate combines exceptional compression characteristics, excellent flowability and good tolerability.
Tricalcium citrate is produced in a unique production process, which creates the special crystalline structure responsible for its outstanding characteristics.
Tricalcium Citrate has high calcium content of 21%, and is the most commonly used calcium salt of citric acid.
Tricalcium citrate is odorless, crystalline powder and is slightly soluble in water and freely soluble in diluted hydrochloric acid.
Tricalcium citrate has low reactivity compared to other calcium salts.
Tricalcium citrate is highly bioavailable calcium source in foods, beverages and pharmaceuticals.
Tricalcium citrate is used as a Sequestering and stabilizing agent in food, firming agent for fruits and vegetables.
Tricalcium citrate Tetrahydrate is calcium salt of citric acid, it is a white, odourless, crystalline powder or fine powder.
Tricalcium citrate is slightly soluble in water and freely soluble in diluted hydrochloric acid.
The main function is to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets.
Tricalcium citrate, also referred to as tricalcium dicitrate tetrahydrate, is produced by neutralizing citric acid with a high quality calcium source such as calcium carbonate or calcium hydroxide.
Tricalcium citrate is the most commonly used calcium salt of citric acid.
Globally, development of efficient and advanced technology, rising awareness for health, nutrition and food safety, flourishing agriculture industry, growth in end user industries such as, food & beverage and healthcare and advantageous properties of tricalcium citrate such as, better compressibility, and low reactivity compared to other calcium salts are the prime growth drivers of the tricalcium citrate market.
In addition, increase in adoption of tricalcium citrate for application in new industrial verticals, and emerging economies such as China, India and others, will create new opportunities for the tricalcium citrate market.
However, volatile prices and availability of raw materials, availability of substitute compounds, and higher cost of tricalcium citrate as compared to conventional calcium salts are the key restraints for the tricalcium citrate market.
Tricalcium citrate anhydrous is also named tricalcium citrate anhydrous.
Tricalcium citrate is a tribasic salt of citric acid.
Tricalcium citrate is manufactured from tricalcium citrate tetrahydrate.
Water molecules of the tetrahydrate crystals are removed by a patented process without destroying the original crystal matrix.
Tricalcium citrate occurs as colorless crystalline powder.
Tricalcium citrate is insoluble in water and practically soluble in acid.
Tricalcium citrate anhydrous is used as chelating agent, buffering agent,tissue coagulator,calcium fortifier and emulsifying salt.
The absorption effect is more superior than inorganic calcium when it’s used as food calcium enhancer.
Tricalcium citrate can be made chewable tablet, granule, capsule and oral liquid in pharmaceutical because it can be easier absorbed by the body than the calcium carbonate.
Tricalcium citrate is a calcium salt of citric acid commonly used as a food additive, dietary supplement, and pharmaceutical excipient.
Tricalcium citrate is recognized for its high bioavailability of calcium, making it an ideal choice for fortifying foods and beverages.
Chemically, Tricalcium citrate is represented as Ca₃(C₆H₅O₇)₂ and appears as a fine, white, odorless powder that is soluble in water and slightly soluble in alcohol.
Tricalcium citrate serves as an acidity regulator, sequestrant, and stabilizer in various food products, including dairy, baked goods, and beverages.
Additionally, Tricalcium citrate is used in the pharmaceutical industry to enhance calcium intake, supporting bone health and preventing conditions such as osteoporosis.
Tricalcium citrate is also favored for its non-toxic nature, compatibility with diverse formulations, and ease of incorporation into different applications.
Tricalcium citrate, a naturally occurring chemical in most plants and animals, is the calcium salt derived from citric acid.
Tricalcium citrate is present in foods which have naturally occurring citric acid.
Tricalcium citrate is used as a calcium supplement and may be used to treat conditions caused by low calcium levels such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany).
Tricalcium citrate is white powder, odorless, slightly hygroscopic.
Tricalcium citrate is slightly soluble in water, soluble in acid, almost insoluble in ethanol.
The crystal water is heated to 100 ° C to gradually lose moisture, and completely loses water at 120 ° C.
Tricalcium citrate may be chemopreventive for colon and other cancers.
Tricalcium citrate is used as an ingredient in dietary supplements, and as a nutrient, sequestrant, buffer, antioxidant, firming agent, acidity regulator (in jams and jellies, soft drinks and wines), as a raising agent and an emulsifying salt.
Tricalcium citrate is also used to improve the baking properties of flours and as a stabilizer.
Tricalcium citrate is the calcium salt of citric acid.
Tricalcium citrate is commonly used as a food additive (E333), usually as a preservative, but sometimes for flavor.
In this sense, Tricalcium citrate is similar to sodium citrate.
Tricalcium citrate is also used as a water softener because the citrate ions can chelate unwanted metal ions.
Tricalcium citrate is also found in some dietary calcium supplements (e.g. Citracal).
Calcium makes up 21% of calcium citrate by weight.
Tricalcium citrate is an organic calcium salt composed of calcium cations and citrate anions in a 3:2 ratio.
Tricalcium citrate has a role as a nutraceutical, a food additive, a food preservative and a flavouring agent.
Tricalcium citrate contains a citrate(3-).
Tricalcium citrate is a type of calcium salt derived from citric acid.
Tricalcium citrate is an important mineral supplement used in a variety of applications, including dietary supplements, food fortification, and laboratory experiments.
Tricalcium citrate has several advantages over other forms of calcium supplementation, such as better absorption and solubility in water.
Tricalcium citrate is used in a variety of scientific research applications.
Tricalcium citrate is often used as a buffer in biochemical and physiological experiments.
Tricalcium citrate can also be used as a nutrient supplement in cell culture media.
Tricalcium citrate is also used in the production of pharmaceuticals and cosmetics.
Additionally, Tricalcium citrate is used in the production of food additives and food fortification.
Tricalcium citrate is a mineral supplement that is absorbed into the body through the digestive system.
Once absorbed, Tricalcium citrate is transported to the bones and other tissues where it is used for various biochemical processes.
Tricalcium citrate is also used to regulate the electrical activity of the heart and other organs.
Additionally, Tricalcium citrate is used to regulate the activity of certain enzymes and hormones.
Tricalcium citrate is the calcium salt of citric acid.
Tricalcium citrate is commonly used as a food additive (E333), usually as a preservative, but sometimes for flavor.
In this sense, Tricalcium citrate is similar to sodium citrate.
Tricalcium citrate is also found in some dietary calcium supplements (e.g. Citracal or Caltrate).
Calcium makes up 24.1% of calcium citrate (anhydrous) and 21.1% of calcium citrate (tetrahydrate) by mass.
The tetrahydrate occurs in nature as the mineral Earlandite.
Tricalcium citrate (sometimes called tricalcium citrate) is found in the following products:
Certain brands of calcium-fortified orange juice
Citracal
GNC Calcimate Plus 800
Solgar Calcium Citrate
TwinLab Calcium Citrate Caps
Applications of Tricalcium Citrate:
Tricalcium citrate has diverse applications across multiple industries due to its high calcium content, stability, and safety profile.
In the food industry, Tricalcium citrate is extensively used as a fortifying agent in products such as dairy alternatives, juices, baked goods, and nutritional supplements, providing essential calcium without altering taste or texture.
Tricalcium citrate’s role as a stabilizer, acidity regulator, and sequestrant ensures consistency and enhances shelf life in processed foods and beverages.
In the pharmaceutical sector, tricalcium citrate is a key ingredient in calcium supplements and formulations aimed at preventing or treating osteoporosis, hypocalcemia, and other calcium-deficiency-related conditions.
Additionally, Tricalcium citrate is incorporated into specialized dietary products designed for children, pregnant women, and the elderly to meet their specific nutritional needs.
Tricalcium citrate also finds use in veterinary medicine and animal feed to promote skeletal health and growth.
Tricalcium citrate’s versatility, compatibility with various formulations, and non-toxic nature make it a preferred choice in a wide range of health, food, and wellness applications.
Pharmaceutical Applications:
Tricalcium citrate is more easily absorbed (bioavailability is 2.5 times higher than calcium carbonate); Tricalcium citrate is easier to digest and less likely to cause constipation and gas than calcium carbonate.
Tricalcium citrate can be taken without food and is more easily absorbed than calcium carbonate on an empty stomach.
Tricalcium citrate is also believed that it contributes less to the formation of kidney stones.
Tricalcium citrate consists of around 24% Ca2+, which means that 1000 mg calcium citrate contains around 240 mg Ca2+.
The lower Ca2+ content together with the higher price makes Tricalcium citrate a more expensive treatment option compared to calcium carbonate, but its slightly different application field can justify this.
Uses of Tricalcium Citrate:
Tricalcium citrate tetrahydrate may be used as raw material in the preparation of nanoparticle with the nominal composition Ca0.8 Ba0.2 Ti03 :Pr3+, via sol-gel process.
Tricalcium citrate may be employed as carbon source in a simple and effective carbonization method to prepare porous carbon without any activation process.
Tricalcium citrate is suitable for use in the preparation of bovine serum albumin (BSA) nanoparticles.
Tricalcium Citrate is produced by complete neutralization of citric acid with a calcium source.
With Tricalcium citrate’s high calcium content of 21 %, it is the most economic calcium salt among the commonly used organic calcium salts.
Due to its functional properties, high bioavailability and health benefits, Tricalcium citrate is widely used as a calcium source in foodstuffs, nutrional supplements, dietary products and pharmaceutical applications.
Some calcium phosphates derive from phosphate rocks, calcium from plant sources, and ammonia.
These can be considered vegan.
Most of the time, however, calcium phosphates are made from ground animal bones.
Calcium phosphate aids in cell functioning and plays a vital role in many different body processes, including bone growth and energy production.
Tricalcium phosphate is effective as a nutritional supplement because Tricalcium citrate is readily absorbed in the body.
However, there is little evidence to show Tricalcium citrate is more effective than other calcium supplements, in particular, those containing citrate and carbonateTrusted Source.
Tricalcium citrate also has many other uses.
Tricalcium citrate is found in many household items, including baby powder, toothpaste, and antacids.
A variety of industries use Tricalcium citrate.
For example, the biomedical sector uses Tricalcium citrate to make cement or composite to repair bones
Tricalcium citrate is an essential mineral that supports multiple systems throughout the body.
You need to maintain adequate calcium levels in order for your heart, nervous system, and muscles to function properly.
When you don’t get enough calcium from outside sources, such as food or supplements, your body dips into the calcium bank stored in your bones to keep blood levels up.
Over time, pulling calcium from your bones weakens them and increases the risk of fracture.
Beyond bones, additional possible benefits of calcium supplementation include improvements in blood pressure and weight loss.
Here’s what the research says.
Blood pressure:
Although the underlying mechanism is unclear, calcium has been associated with reducing blood pressure in multiple studies.
However, there are rising concerns that excessive calcium through supplements may harden arteries and pose cardiovascular risks.
Weight loss:
When people are placed on low-calorie diets, studies show that adding calcium and vitamin D supplements improves their rate of fat loss while preserving muscle and bone mass.
As with many dietary supplements, taking more calcium than we need probably does more harm than good.
Instead of blindly adding calcium citrate, only purchase a supplement if you know you aren’t getting enough from food and beverages.
The following granulation types are available:
Micronised Powder
Powder
Granular
Tricalcium citrate is supplied in polyethylene lined paper bags.
Net quantity is 10, 15, 20 or 25 kg, depending on the individual bulk density of the desired granulation.
Properties of Tricalcium Citrate:
One of the special salts produced by our partner Jungbunzlauer, Tricalcium Citrate is a fine white odorless powder with high calcium content (21%).
This ingredient has a neutral taste and high bio-availability.
Due to its superior technological and nutritional properties, Tricalcium Citrate can be used for mineral enrichment in food, beverages, nutraceutical and pharmaceutical products.
Tricalcium citrate with special crystal structure leading to exceptional flowability,
Enables production of hard tablets even at low compression forces,
Displays excellent disintegration properties,
Calcium in citrate form with good tolerability and compatibility,
Biological Activity of Tricalcium Citrate:
In many individuals, bioavailability of Tricalcium citrate is found to be equal to that of the cheaper calcium carbonate.
However, alterations to the digestive tract may change how calcium is digested and absorbed.
Unlike calcium carbonate, which is basic and neutralizes stomach acid, Tricalcium citrate has no effect on stomach acid.
Individuals who are sensitive to antacids or who have difficulty producing adequate stomach acid should choose Tricalcium citrate over calcium carbonate for supplementation.
According to recent research into calcium absorption after gastric bypass surgery , Tricalcium citrate may have improved bioavailability over calcium carbonate in Rouxen- Y gastric bypass patients who are taking calcium citrate as a dietary supplement after surgery.
Tricalcium citrate is mainly due to the changes related to where calcium absorption occurs in the digestive tract of these individuals.
Production Methods of Tricalcium Citrate:
Tricalcium citrate is an intermediate in the isolation of citric acid from the fermentation process by which citric acid is produced industrially.
The citric acid in the broth solution is neutralized by calcium hydroxide, precipitating insoluble Tricalcium citrate.
This is then filtered off from the rest of the broth and washed to give clean Tricalcium citrate.
The calcium citrate thus produced may be sold as-is, or Tricalcium citrate may be converted to citric acid using dilute sulfuric acid.
3 Ca(OH)2(s) + 2 C6H8O7(l) → Ca3(C6H5O7)2(s) + 6 H2O(l)
The Tricalcium citrate thus produced may be sold as-is, or Tricalcium citrate may be converted to citric acid using dilute sulfuric acid.
Synthesis Method of Tricalcium Citrate:
Tricalcium citrate is synthesized by combining calcium hydroxide and citric acid.
Calcium hydroxide is a white, odorless powder that is soluble in water.
Citric acid is a weak organic acid that is found naturally in citrus fruits.
The synthesis of Tricalcium citrate is a simple and straightforward process.
First, the calcium hydroxide and citric acid are mixed together in a ratio of 1:2.
The mixture is then heated to a temperature of 80-90°C.
At this temperature, the calcium hydroxide reacts with the citric acid to form calcium citrate.
The reaction is complete when the mixture has cooled to room temperature.
Handling and Storage of Tricalcium Citrate:
Handling:
Avoid inhalation of dust and prolonged skin or eye contact.
Use in well-ventilated areas to prevent dust accumulation.
Wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and masks.
Storage:
Store in a cool, dry, and well-ventilated area away from moisture, acids, and incompatible materials.
Keep the container tightly closed and properly labeled.
Protect from excessive heat and direct sunlight.
Stability and Reactivity of Tricalcium Citrate:
Stability:
Stable under normal temperature and pressure conditions.
May decompose at high temperatures, releasing calcium oxide and carbon dioxide.
Reactivity:
Reacts with strong acids to produce citric acid and calcium salts.
Avoid contact with strong oxidizing agents and moisture to prevent degradation.
Hazardous Decomposition Products:
Calcium oxides and carbon oxides under combustion or extreme heat.
First Aid Measures of Tricalcium Citrate:
Inhalation:
Move to fresh air and keep comfortable for breathing.
Seek medical attention if symptoms persist.
Skin Contact:
Wash the affected area with soap and water.
Remove contaminated clothing.
Seek medical attention if irritation develops.
Eye Contact:
Rinse cautiously with water for several minutes.
Remove contact lenses if present and easy to do.
Seek medical attention if irritation persists.
Ingestion:
Rinse mouth thoroughly.
Drink water to dilute.
Do not induce vomiting unless directed by medical personnel.
Seek medical attention if symptoms occur.
Firefighting Measures of Tricalcium Citrate:
Suitable Extinguishing Media:
Use water spray, dry chemical, foam, or carbon dioxide.
Specific Hazards:
Tricalcium citrate is not flammable but may decompose at high temperatures, releasing calcium oxide and irritating fumes.
Protective Equipment for Firefighters:
Wear self-contained breathing apparatus (SCBA) and full protective clothing.
Special Instructions:
Prevent run-off from entering water systems.
Accidental Release Measures of Tricalcium Citrate:
Personal Precautions:
Evacuate the area if necessary and ensure adequate ventilation.
Use PPE, including gloves, goggles, and respiratory protection, to minimize exposure.
Environmental Precautions:
Prevent product from entering waterways, drains, or soil.
Cleanup Methods:
Contain and collect spilled material using non-sparking tools.
Sweep or vacuum the material and transfer it to a suitable container for disposal.
Avoid creating dust.
Disposal:
Dispose of in accordance with local, regional, and national regulations.
Exposure Controls/Personal Protective Measures of Tricalcium Citrate:
Engineering Controls:
Use local exhaust ventilation or general ventilation to minimize dust exposure.
Personal Protective Equipment (PPE):
Respiratory Protection:
Use a dust mask or respirator when handling in dusty environments.
Eye Protection:
Safety goggles or face shield.
Skin Protection:
Gloves and protective clothing to prevent prolonged contact.
Hygiene Measures:
Wash hands and face thoroughly after handling.
Avoid eating, drinking, or smoking in work areas.
Exposure Limits:
No specific occupational exposure limits established, but minimizing inhalation and contact is recommended.
Identifiers of Tricalcium Citrate:
Chemical Name: Tricalcium citrate
Molecular Formula: Ca₃(C₆H₅O₇)₂
Molar Mass: 498.46 g/mol
CAS Number: 5785-44-4
E Number: E333 (used as a food additive)
Appearance: White, fine, odorless powder
Solubility: Slightly soluble in water; insoluble in alcohol
pH Range: 5–9 (depending on concentration in solution)
Melting Point: Decomposes without melting
Density: Approximately 1.6 g/cm³
CAS number: 5785-44-4
EC number: 212-391-7
Grade: DAC,USP,E 333,FCC
Hill Formula: C₁₂H₁₀Ca₃O₁₄ * 4 H₂O
Molar Mass: 570.51 g/mol
HS Code: 2918 15 00
Storage class: 10 – 13 Other liquids and solids
WGK: WGK 1 slightly hazardous to water
Disposal: 3
Properties of Tricalcium Citrate:
Appearance: White, fine, odorless powder.
Molecular Formula: Ca₃(C₆H₅O₇)₂.
Molecular Weight: 498.46 g/mol.
Density: ~1.6 g/cm³.
Solubility: Slightly soluble in water (~0.85 g/L at 25°C); insoluble in alcohol.
Melting Point: Decomposes without melting.
Solubility: 0.1 M HCl: 0.01 M at 20 °C, clear, colorless
Odor: at 100.00%. odorless
Stability: Stable. Incompatible with strong oxidizing agents.
LogP: -1.721 (est)
CAS DataBase Reference: 813-94-5(CAS DataBase Reference)
EPA Substance Registry System: Tricalcium citrate (813-94-5)
pH value: 5 – 6 (25 g/l, H₂O, 20 °C) (slurry)
Bulk density: 350 kg/m3
Solubility: 0.85 g/l
Specifications of Tricalcium Citrate:
Assay (complexometric; calculated on dried substance): 98.0 – 100.5 %
Identity (wet chemistry): passes test
Appearance: white to almost white, fine powder
Appearance of solution: (50 g/l, hydrochloric acid 0.8 mol/l) not more turbid than 18 NTU and not more intense in color than reference solution BY₆
Substances insoluble in hydrochloric acid: ≤ 0.2 %
pH (25 g/l, after boiling in water): 5.0 – 6.0
Carbonate (as CO₂): passes test
Fluoride (F): ≤ 30 ppm
Al (Aluminium): ≤ 30 ppm
As (Arsenic): ≤ 1 ppm
As (Arsenic) (ICP): ≤ 1 ppm
Cd (Cadmium)*: ≤ 0.2 ppm
Fe (Iron): ≤ 100 ppm
Fe (Iron) (ICP): ≤ 100 ppm
Mn (Manganese): ≤ 50 ppm
Ni (Nickel)*: ≤ 2 ppm
Hg (Mercury): ≤ 1 ppm
Pb (Lead): ≤ 1 ppm
Pb (Lead) (ICP): ≤ 1 ppm
Oxalates (as C₂H₂O₄, calc. on dried substance): ≤ 100 ppm
Readily carbonisable substance: passes test
Residual solvents (ICH Q3C): excluded by manufacturing process
Loss on drying (150 °C, 4 h): 11.5 – 13.3 %
Total aerobic microbial count (TAMC): ≤ 1000 CFU/g
Total combined yeasts/moulds count (TYMC): ≤ 100 CFU/g
Names of Tricalcium Citrate:
IUPAC Name:
2-hydroxy-1,2,3-propane- tricarboxylic acid calcium salt (2:3)
2-hydroxypropane-1,2,3-tricarboxylate
calcium citrates
tri-Calcio di-Citrato 4-hidrato
Tricalcium 2-hydroxypropane-1,2,3-tricarboxylate