TRISODIUM CITRATE
TRISODIUM CITRATE
Trisodium citrate appears as a white crystalline powder or granular crystals and, given Trisodium citrate is a salt, possesses a salty / saline taste with no real detectable odour.
Trisodium citrate is a chemical compound, the sodium salt of Citric Acid.
Trisodium citrate is obtained by reacting Sodium Citrate with sodium hydroxide, carbonate, or bicarbonate and then crystallized and dehydrated.
CAS Number: 68-04-2
EC number: 200-675-3
Chemical Formula: Na3C6H5O7
Molar Mass: 294.10 g/mol
Synonyms: Trisodium citrate dihydrate, Sodium citrate dihydrate, 6132-04-3, Sodium citrate tribasic dihydrate, Sodium citrate hydrate, 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, trisodium salt, dihydrate, Citric acid trisodium salt dihydrate, Sodium citrate hydrous, SODIUM CITRATE, DIHYDRATE, trisodium 2-hydroxypropane-1,2,3-tricarboxylate dihydrate, MFCD00150031, B22547B95K, trisodium;2-hydroxypropane-1,2,3-tricarboxylate;dihydrate, DTXSID1049437, Natrum citricum, Citric acid, trisodium salt, dihydrate, Citronensaeure,Trinatrium-Salz-Dihydrat, N-1560, Natrii citras, dehydrate, SODIUM CITRATE HYDROUS (II), SODIUM CITRATE HYDROUS [II], trisodium 2-hydroxypropane-1,2,3-tricarboxylate–water (1/2), Trisodium citrate dihydrate;Citric acid trisodium salt dihydrate, 2-hydroxy-1,2,3-propanetricarboxylic acid trisodium salt dihydrate, MFCD00130806, SODIUM CITRATE (EP MONOGRAPH), SODIUM CITRATE [EP MONOGRAPH], tri-sodium citrate dihydrate, TRISODIUM CITRATE DIHYDRATE (II), TRISODIUM CITRATE DIHYDRATE [II], UNII-B22547B95K, TRISODIUM CITRATE DIHYDRATE (USP MONOGRAPH), TRISODIUM CITRATE DIHYDRATE [USP MONOGRAPH], sodium 2-hydroxypropane-1,2,3-tricarboxylate dihydrate, Sodiumcitrate, Tricitrasol, Tricitrasol (TN), Sodium citrate; Trisodium 2-hydroxypropane-1,2,3-tricarboxylate dihydrate; Sodium Citrate Dihydrate, Sodium citrate (TN), 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, sodium salt, hydrate (1:3:2), D05KTE, Sodium citrate [USP:JAN], Sodiumcitratetribasicdihydrate, SODIUM CITRATE [FHFI], DTXCID0029397, Sodium citrate hydrate (JP17), CHEBI:32142, Trisodium citrate dihydrate, ACS, NLJMYIDDQXHKNR-UHFFFAOYSA-K, SODIUM CITRATE HYDRATE [JAN], SODIUM CITRATE DIHYDRATE [MI], AKOS025293920, Sodium citrate dihydrate, >=99%, FG, SODIUM CITRATE DIHYDRATE [VANDF], BP-31019, SODIUM CITRATE DIHYDRATE [WHO-DD], Sodium citrate tribasic dihydrate, >=98%, Sodium citrate dihydrate, ACS reagent grade, SODIUM CITRATE, DIHYDRATE [WHO-IP], D01781, F82065, Sodium citrate tribasic dihydrate, AR, >=99%, Sodium citrate tribasic dihydrate, LR, >=99%, Citric acid trisodium salt dihydrate ACS reagent, NATRII CITRAS, DEHYDRATE [WHO-IP LATIN], A833161, A835986, Q22075862, Sodium citrate dihydrate Biochemical grade, Fine Granular, Sodium citrate tribasic dihydrate, USP, 99.0-100.5%, Sodium Citrate Tribasic Dihydrate (Molecular Biology Grade), Sodium citrate tribasic dihydrate, ACS reagent, >=99.0%, trisodium 2-oxidanylpropane-1,2,3-tricarboxylate dihydrate, Citric acid trisodium salt dihydrateTrisodium citrate dihydrate, Sodium citrate tribasic dihydrate, BioUltra, >=99.0% (NT), Sodium citrate tribasic dihydrate, insect cell culture tested, Sodium citrate tribasic dihydrate, JIS special grade, >=99.0%, Sodium citrate tribasic dihydrate, p.a., ACS reagent, 99.0%, Sodium citrate tribasic dihydrate, purum p.a., >=99.0% (NT), Sodium citrate tribasic dihydrate, SAJ first grade, >=99.0%, Sodium citrate tribasic dihydrate, tested according to Ph.Eur., Trisodium citrate dihydrate, meets USP testing specifications, Sodium citrate tribasic dihydrate, BioXtra, >=99.0% (titration), Sodium citrate tribasic dihydrate, for molecular biology, >=99%, Sodium citrate tribasic dihydrate, Vetec(TM) reagent grade, 98%, Sodium citrate, United States Pharmacopeia (USP) Reference Standard, 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, sodium salt, dihydrate, 2-Hydroxy-1,2,3-propanetricarboxylic acid, trisodium salt, dihydrate, Sodium citrate tribasic dihydrate, p.a., ACS reagent, reag. ISO, 99-101%, Sodium citrate tribasic dihydrate, BioUltra, for molecular biology, >=99.5% (NT), Sodium citrate tribasic dihydrate, puriss. p.a., ACS reagent, >=99.0% (NT), Sodium citrate tribasic dihydrate, suitable for amino acid analysis, >=99.0%, Sodium Citrate, Pharmaceutical Secondary Standard; Certified Reference Material, Sodium citrate tribasic dihydrate, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., >=99.5%, Sodium citrate tribasic dihydrate, suitable for amino acid analysis, >=98% (titration), powder, Trisodium citrate [ACD/IUPAC Name] [Wiki], 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, sodium salt (1:3) [ACD/Index Name], 200-675-3 [EINECS], 68-04-2 [RN], 994-36-5 [RN], Citrate de trisodium [French] [ACD/IUPAC Name], Citric Acid Trisodium Salt, MFCD00012462 [MDL number], RS7A450LGA, Sodium 2-hydroxy-1,2,3-propanetricarboxylate, Sodium Citrate [JAN] [USAN] [Wiki], Sodium citrate anhydrous, Trinatriumcitrat [German] [ACD/IUPAC Name], Tris sodium citrate, trisodium 2-hydroxypropane-1,2,3-tricarboxylate, 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, trisodium salt, 114456-61-0 [RN], 205-623-3 [EINECS], 2-Hydroxy-1,2,3-propanenetricarboxylic acid trisodium salt, 2-Hydroxy-1,2,3-propanetricarboxylic acid trisodium salt, 2-Hydroxy-1,2,3-propanetricarboxylic acid, trisodium salt, Citnatin, Citrate Concentratedmissing, citrate sodium, citrate trisodium, Citratemissing, Citreme, Citric acid sodium salt anhydrous, Citric acid trisodium salt, anhydrous, Citric acid, trisodium salt, Citrosodina, Citrosodine, Citrosodna, Isolyte E, Natrocitral, Sodium 2-hydroxypropane-1,2,3-tricarboxylate, Sodium citrate (USP), Sodium citrate buffer, SODIUM CITRATE TRIBASIC, Sodium citrate, anhydrous, Synthesis on demand, tri-sodium citrate, Trisodium citrate anhydrous, tris-sodium citrate, UNII-RS7A450LGA
Trisodium citrate has the chemical formula of Na3C6H5O7.
Trisodium citrate is sometimes referred to simply as “sodium citrate”, though Trisodium citrate can refer to any of the three sodium salts of citric acid.
Trisodium citrate possesses a saline, mildly tart flavor, and is a mild alkali.
Trisodium citrate is mildly basic and can be used along with Sodium Citrate to make biologically compatible buffers.
Trisodium citrate has the chemical formula Na3C6H5O7.
Trisodium citrate can refer to any of the three sodium salts of citric acid.
Trisodium citrate is lightweight and can be used with Sodium Citrate to make biocompatible buffers.
Trisodium citrate, one of the sodium salts of citric acid, is a compound found in every living organism and is part of key metabolic pathways in all body cells.
Trisodium citrate is found in high concentrations in sour fruits, kiwis, strawberries and many other fruits.
Trisodium citrate is commercially prepared by the fermentation of molasses by the mold Aspergillus niger.
Trisodium citrate, also referred to as Sodium Citrate, Trisodium Salt or food additive E331, is the tribasic salt of citric acid.
Trisodium citrate appears as a white crystalline powder or granular crystals and, given Trisodium citrate is a salt, possesses a salty / saline taste with no real detectable odour.
Trisodium citrate has the CAS number 6132-04-3 and formula Na3C6H5O7.
Trisodium citrate is water-soluble, non-toxic and fully biodegradable.
Trisodium citrate is the sodium salt of citric acid.
Trisodium citrate is white, crystalline powder or white, granular crystals, slightly deliquescent in moist air, freely soluble in water, practically insoluble in alcohol.
Like Sodium Citrate, Trisodium citrate has a sour taste.
From the medical point of view, Trisodium citrate is used as alkalinizing agent.
Trisodium citrate works by neutralizing excess acid in the blood and urine.
Trisodium citrate has been indicated for the treatment of metabolic acidosis.
Trisodium citrate is a chemical compound, the sodium salt of Citric Acid.
Trisodium citrate is obtained by reacting Sodium Citrate with sodium hydroxide, carbonate, or bicarbonate and then crystallized and dehydrated.
Trisodium citrate also occurs naturally in citrus fruits.
Trisodium citrate is commonly referred to as ‘Sodium Citrate’, but this term is ambiguous as Trisodium citrate can also refer to the sodium or monosodium salt.
Trisodium citrate is structured in such a way that a sodium atom is attached to each of the three carboxyl groups present.
Similarly, Monosodium Citrate is a chemical compound with one sodium in the molecule and Disodium Citrate is a chemical compound with two sodium atoms.
Trisodium citrate is labeled as a food additive with the symbol E331.
Trisodium citrate is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum. Trisodium citrate is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing. Trisodium citrate is a tribasic salt of citric acid. Trisodium citrate is produced by complete neutralisation of citric acid with high purity sodium hydroxide or carbonate and subsequent crystallisation and dehydration. The common hydrate form, Trisodium citrate dihydrate, is widely used in foods, beverages and various technical applications mainly as buffering, sequestering or emulsifying agent. Trisodium citrate anhydrous is manufactured from Trisodium citrate dihydrate. Water molecules of the dihydrate crystals are removed by a patented process without destroying the original crystal matrix. The resulting crystals have a porous matrix that can be used as a carrier for inorganic and/or organic substances like perfumes and surfactants. Due to Trisodium citrate low water content Trisodium citrate anhydrous does not add water to the formulation. Trisodium citrate has even the excellent ability to take up surplus water from moisture sensitive formulations thus providing better shelf life to the end product. Therefore, Trisodium citrate anhydrous finds Trisodium citrate particular uses in water sensitive formulations like instant drinks as well as tablets and powders in pharmaceuticals and detergents. Trisodium citrate anhydrous occurs as white, granular crystals or as white, crystalline powder. Trisodium citrate is freely soluble in water and practically insoluble in ethanol (96 %). Trisodium citrate is a non-toxic, neutral salt with low reactivity. Trisodium citrate is chemically stable if stored at ambient temperatures. Trisodium citrate anhydrous is fully biodegradable and can be disposed of with regular waste or sewage. Trisodium citrate dihydrate, is widely applied in food, beverages and fillers as a buffering, sequestering or an emulsifying agent. Trisodium citrate used as an anticoagulant in blood transfusions, osmotic laxative, functional fluids, solvents cleaning, furnishing care products, laundry dishwashing products and cleaning automobile radiators. Trisodium citrate dihydrate is a tribasic salt of citric acid. Trisodium citrate is produced by complete neutralisation of Trisodium citrate with high purity sodium hydroxide or carbonate and subsequent crystallisation. Trisodium citrate dihydrate is widely used in foods, beverages and various technical applications mainly as buffering, sequestering or emulsifying agent. Trisodium citrate dihydrate occurs as white, granular crystals or as white, crystalline powder with a pleasant, salty taste. Trisodium citrate is slightly deliquescent in moist air, freely soluble in water and practically insoluble in ethanol (96 %). Trisodium citrate dihydrate is a non-toxic, neutral salt with low reactivity. Trisodium citrate is chemically stable if stored at ambient temperatures. Trisodium citrate dihydrate is fully biodegradable and can be disposed of with regular waste or sewage. Trisodium citrate in Food: Trisodium citrate is a food additive with the E number E331. Trisodium citrate is used in a variety of processed food and drink primarily as a flavour enhancer and a preservative. As an emulsifying agent Trisodium citrate is also used in cheesemaking to allow cheese to melt without the separation of oils and fats. Trisodium citrate in food buffers pH levels to help regulate acidity in a variety of foods to balance taste and is also able to impart a tart / sour flavour in a wide variety of drink products. Usage areas of Trisodium citrate: Trisodium citrate is often used as a food additive as a flavoring or preservative. The E number is E331. Trisodium citrate is used as a flavoring agent in certain varieties of club soda. Trisodium citrate is common as an ingredient in Bratwurst and is also commercially available for drinks and beverage mixes, contributing a tart flavor. Trisodium citrate is found in gelatin mix, ice cream, jam, desserts, powdered milk, processed cheeses, sodas and wine. Trisodium citrate can be used as an emulsifier when making cheese. Trisodium citrate allows the cheese to melt without remaining greasy. Trisodium citrate, a conjugate base of a weak acid, can act as a buffering agent or acidity regulator by resisting change in pH. Trisodium citrate is used to control the acidity of some substances, such as gelatin desserts. Trisodium citrate is found in mini milk containers used in coffee machines. Trisodium citrate is a particularly effective substance for removing carbonate scale from boilers without cracking and for cleaning car radiators. Uses of Trisodium citrate: Trisodium citrate has many uses, but is mainly applied in the food industry. Trisodium citrate has similar applications as Citric Acid, so Trisodium citrate is usually used as a flavor enhancer, to acidify foods or beverages, or as a preservative. Trisodium citrate is also commonly used in medicine as a drug ingredient, usually for people with urinary tract infections. Trisodium citrate also plays a role as an anticoagulant, which means Trisodium citrate inhibits blood clotting. In addition, Trisodium citrate is used in chemistry. Trisodium citrate is a component of buffers and a component of Benedict’s reagent, which is used to detect sugars and aldehydes. Trisodium citrate is also found in cosmetics such as shower gels, shampoos or skin creams, as Trisodium citrate gives them the right acidity level and is used as a preservative. Another application of Trisodium citrate is to remove scale from boilers, clean car radiators, and burnt sheet metal or pots. Trisodium citrate is also used in the production of cleaning products, as it softens water, allowing detergents to work more effectively. Trisodium citrate is used in similar applications to citric acid. These uses include as an acidity regulator in food and drink, as a sequestering agent to prevent limescale inference with soaps and detergents and as an emulsifying agent to aid chemical mixing processes where two separate elements are incapable of mixing (for example oil and water) and helps to keep these mixtures stable once formulated. Trisodium citrate is used in blood collection (anticoagulant), photography, and food production. (sequestering agent, emulsifier, and acidulant) Permitted for use as an inert ingredient in non-food pesticide products. Trisodium citrate in food industry: Foods: Trisodium citrate is chiefly used as a food additive, usually for flavor or as a preservative. Trisodium citrate E number is E331. Trisodium citrate is employed as a flavoring agent in certain varieties of club soda. Trisodium citrate is common as an ingredient in bratwurst, and is also used in commercial ready-to-drink beverages and drink mixes, contributing a tart flavor. Trisodium citrate is found in gelatin mix[clarification needed], ice cream, yogurt, jams, sweets, milk powder, processed cheeses, carbonated beverages, and wine[citation needed], amongst others. As a conjugate base of a weak acid, citrate can perform as a buffering agent or acidity regulator, resisting changes in pH. Trisodium citrate is used to control acidity in some substances, such as gelatin desserts. Trisodium citrate can be found in the milk minicontainers used with coffee machines. Trisodium citrate is the product of antacids, such as Alka-Seltzer, when they are dissolved in water. The pH of a solution of 5 g/100 ml water at 25 °C is 7.5 – 9.0. Trisodium citrate is added to many commercially packaged dairy products to control the PH impact of the gastrointestinal system of humans, mainly in processed products such as cheese and yogurt. Trisodium citrate can be used to optimize the safety and quality of snacks, cereals, bakery products and potato products such as French fries without affecting the production process. Trisodium citrate is found in carbonated beverages, dairy products, confectionery, prepared foods, canned meats and vegetables, margarine, mustard, sauces, mayonnaise, spices, jams, and much more. This is not surprising, because Trisodium citrate has various properties that are important for the food industry. Firstly, Trisodium citrate is used as an acidity regulator to maintain the proper pH of Trisodium citrate. Trisodium citrate is found in sodas, especially those with lemon flavor, energy drinks, desserts or jams. Trisodium citrate is a sequestering agent, which means Trisodium citrate is a substance that binds metal ions, called chelates. Thanks to this, the consumer is protected from the harmful effects of heavy metals in foods. Trisodium citrate is also an emulsifier – Trisodium citrate enables the preparation of a uniform solution from two immiscible liquids. Trisodium citrate is useful, for example, in the production of cheese, as Trisodium citrate does not become greasy after melting, because Trisodium citrate prevents the separation of fats. Another use of Trisodium citrate in the food industry is as a preservative. Trisodium citrate protects the fats in Trisodium citrate from oxidation and rancidity. Trisodium citrate also prevents color changes in foods. Medical uses: In 1914, the Belgian doctor Albert Hustin and the Argentine physician and researcher Luis Agote successfully used Trisodium citrate as an anticoagulant in blood transfusions, with Richard Lewisohn determining Trisodium citrate correct concentration in 1915. Trisodium citrate continues to be used today in blood-collection tubes and for the preservation of blood in blood banks. The citrate ion chelates calcium ions in the blood by forming calcium citrate complexes, disrupting the blood clotting mechanism. Recently, Trisodium citrate has also been used as a locking agent in vascath and haemodialysis lines instead of heparin due to Trisodium citrate lower risk of systemic anticoagulation. In 2003, Ööpik et al. showed the use of Trisodium citrate (0.5 g/kg body weight) improved running performance over 5 km by 30 seconds. Trisodium citrate is used to relieve discomfort in urinary-tract infections, such as cystitis, to reduce the acidosis seen in distal renal tubular acidosis, and can also be used as an osmotic laxative. Trisodium citrate is a major component of the WHO oral rehydration solution. Trisodium citrate is used as an antacid, especially prior to anaesthesia, for caesarian section procedures to reduce the risks associated with the aspiration of gastric contents. Trisodium citrate in medicine: Trisodium citrate is not only known as a food additive, but also as an important chemical compound in medicine. Trisodium citrate is used in analytical laboratories where blood tests are performed because Trisodium citrate has an anticoagulant effect. This prevents blood cells from clumping together. Trisodium citrate is then used as a component of solutions for filling hemodialysis catheters. Trisodium citrate lowers the concentration of heparin, which in turn reduces the risks associated with coagulation disorders in patients with kidney disease or blood clotting. This counteracts side effects during and after dialysis treatment. This effect is also extremely useful when storing blood or during transfusions. Trisodium citrate is also used as a drug. Trisodium citrate treats kidney stones, gout and reduces the symptoms of metabolic acidosis. Trisodium citrate can also be used as a laxative. Trisodium citrate can be used for hypercalcemia, a condition in which the concentration of calcium in the blood is too high. Trisodium citrate works by increasing the excretion of calcium through the urine. Consumer Uses: Trisodium citrate is used in the following products: washing & cleaning products, polishes and waxes, air care products, cosmetics and personal care products, water softeners, perfumes and fragrances, water treatment chemicals, coating products, inks and toners, textile treatment products and dyes, biocides (e.g. disinfectants, pest control products), fertilisers, adsorbents, fillers, putties, plasters, modelling clay, laboratory chemicals and photo-chemicals. Other release to the environment of Trisodium citrate is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment), outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)), indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints) and outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials). Widespread uses by professional workers: Trisodium citrate is used in the following products: laboratory chemicals, washing & cleaning products, air care products, perfumes and fragrances, polishes and waxes, water softeners, water treatment chemicals, biocides (e.g. disinfectants, pest control products), coating products, fillers, putties, plasters, modelling clay, inks and toners, textile treatment products and dyes, fertilisers, photo-chemicals, cosmetics and personal care products and adsorbents. Trisodium citrate is used in the following areas: health services, building & construction work, mining, agriculture, forestry and fishing and formulation of mixtures and/or re-packaging. Trisodium citrate is used for the manufacture of: machinery and vehicles and furniture. Other release to the environment of Trisodium citrate is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment), outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)), indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints), indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids). Uses at industrial sites: Trisodium citrate is used in the following products: pH regulators and water treatment products, washing & cleaning products, polishes and waxes and water treatment chemicals. Trisodium citrate is used in the following areas: mining, health services and building & construction work. Trisodium citrate is used for the manufacture of: machinery and vehicles, textile, leather or fur, metals, fabricated metal products, electrical, electronic and optical equipment and chemicals. Release to the environment of Trisodium citrate can occur from industrial use: in processing aids at industrial sites, of substances in closed systems with minimal release, as processing aid, formulation of mixtures and in the production of articles. Other release to the environment of Trisodium citrate is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use. Other Uses: Food: Baby Food, Infant Formula Bakery Cereals, Snacks Confectionery Dairy Dairy Alternatives Desserts, Ice Cream Flavours Fruit Preparations, Sweet Spreads Fruits, Vegetables Meat Alternatives Meat, Seafood Plant-based Products Ready Meals, Instant Food Sauces, Dressings, Seasonings Beverages: Alcoholic Beverages Carbonated Soft Drinks Instant Drinks, Syrups Juice Drinks Plant-based RTD Tea and Coffee Sports and Energy Drinks Waters Healthcare: Clinical Nutrition Medical Devices OTC, Food Supplements Pharmaceutical Products Personal Care: Colour Cosmetics Fragrances Hair Care Oral Care Skin Care Soap and Bath Products Cleaners & Detergents: Dish Washing Industrial Cleaners Laundry Care Surface Care Industrial Applications: Adhesives, Sealants Agrochemicals, Fertilisers Construction Fine Chemicals Inks, Paints, Coatings Oil Drilling Paper Plastics, Polymers Textile, Leather Feed & Pet Food: Feed Pet Food Pharma: Buffering agent Chelating agent Mineral source Industrial Processes with risk of exposure: Photographic Processing Applications of Trisodium citrate: Trisodium citrate dihydrate, is widely applied in food, beverages and fillers as a buffering, sequestering or an emulsifying agent. Trisodium citrate used as an anticoagulant in blood transfusions, osmotic laxative, functional fluids, solvents cleaning, furnishing care products, laundry dishwashing products and cleaning automobile radiators. Foods: Trisodium citrate is chiefly used as a food additive, usually for flavor or as a preservative. Trisodium citrate E number is E331. Trisodium citrate is employed as a flavoring agent in certain varieties of club soda. Trisodium citrate is common as an ingredient in bratwurst, and is also used in commercial ready-to-drink beverages and drink mixes, contributing a tart flavor. Trisodium citrate is found in gelatin mix, ice cream, yogurt, jams, sweets, milk powder, processed cheeses, carbonated beverages, and wine,[3] amongst others. Trisodium citrate can be used as an emulsifying stabilizer when making cheese. Trisodium citrate allows the cheese to melt without becoming greasy by stopping the fats from separating. Buffering: As a conjugate base of a weak acid, citrate can perform as a buffering agent or acidity regulator, resisting changes in pH. Trisodium citrate is used to control acidity in some substances, such as gelatin desserts. Trisodium citrate can be found in the milk minicontainers used with coffee machines. Trisodium citrate is the product of antacids, such as Alka-Seltzer, when they are dissolved in water. The pH of a solution of 5 g/100 ml water at 25 °C is 7.5 – 9.0. Trisodium citrate is added to many commercially packaged dairy products to control the pH impact of the gastrointestinal system of humans, mainly in processed products such as cheese and yogurt, although Trisodium citrate also has beneficial effects on the physical gel microstructure. Chemistry: Trisodium citrate is a component in Benedict's qualitative solution, often used in organic analysis to detect the presence of reducing sugars such as glucose. Medicine: In 1914, the Belgian doctor Albert Hustin and the Argentine physician and researcher Luis Agote successfully used Trisodium citrate as an anticoagulant in blood transfusions, with Richard Lewisohn determining Trisodium citrate correct concentration in 1915. Trisodium citrate continues to be used today in blood-collection tubes and for the preservation of blood in blood banks. The citrate ion chelates calcium ions in the blood by forming calcium citrate complexes, disrupting the blood clotting mechanism. Recently, Trisodium citrate has also been used as a locking agent in vascath and haemodialysis lines instead of heparin due to Trisodium citrate lower risk of systemic anticoagulation. In 2003, Ööpik et al. showed the use of Trisodium citrate (0.5 g/kg body weight) improved running performance over 5 km by 30 seconds. Trisodium citrate is used to relieve discomfort in urinary-tract infections, such as cystitis, to reduce the acidosis seen in distal renal tubular acidosis, and can also be used as an osmotic laxative. Trisodium citrate is a major component of the WHO oral rehydration solution. Trisodium citrate is used as an antacid, especially prior to anaesthesia, for caesarian section procedures to reduce the risks associated with the aspiration of gastric contents. Boiler descaling: Trisodium citrate is a particularly effective agent for removal of carbonate scale from boilers without removing them from operation and for cleaning automobile radiators. Healthcare: Effervescent tablets and preparations: The reaction of citric acid and bicarbonate liberates carbon dioxide, which aids the dissolution of active ingredients and improves palatability. Effervescent systems are widely used in denture-cleaning products, as well as pain relief and vitamin tablets. Pharmaceutically active substances — many are supplied as their citrate salt. pH control: Citric acid, with sodium or potassium citrate, is an efficient buffering system used in a variety of pharmaceutical and cosmetic applications for improving stability and (where appropriate) enhancing the activity of preservatives. Flavor: The sharp, acid taste of citric acid (which is often used to enhance fruit flavors) can help mask the unpleasant, medicinal taste of pharmaceuticals. Antioxidant: The citrate ion is a powerful chelating agent for trace metal ions. Blood anticoagulant: The citrate ion will chelate calcium, thereby reducing the tendency for blood to clot. Diuretic – potassium citrate has diuretic properties. Clinical Nutrition Medical Devices OTC, Food Supplements Pharmaceutical Products Color Cosmetics Deodorants Fragrances Hair Care Oral Care Skin Care Soap and Bath Products Cleaners & Detergents: The major components of cleaning products are surfactants and builders. Other ingredients are added to provide a variety of functions, e.g., increasing cleaning performance for specific soils/surfaces, ensuring product stability, and supplying a unique identity to a product. Complex phosphates and Trisodium citrate are common sequestering builders. Builders enhance or maintain the cleaning efficiency of the surfactant. The primary function of builders is to reduce water hardness. This is done either by sequestration or chelation (holding hardness minerals in solution); by precipitation (forming an insoluble substance); or by ion exchange (trading electrically charged particles). Builders can also supply and maintain alkalinity, which assists cleaning, especially of acid soils; help keep removed soil from redepositing during washing, and emulsify oily and greasy soils. Dish Washing Industrial Cleaners: Laundry Care Surface Care: Industrial Sodium Citrate is employed as an industrial cleaner to clear steam blocks and hot water systems of calcium and rust layers. As a chemical polish, Sodium Citrate is used to treat aluminum, copper and other metal surfaces. Sodium Citrate and citrates are used as buffering and complexing agents in electro-plating baths. The building and textile industries also take advantage of Sodium Citrate’s outstanding chelating ability as well as Trisodium citrate non-toxicity. Examples include set retarding of gypsum plasters and textile finishing. Further industrial applications of Sodium Citrate and citrates range from desulphurisation of flue gas and oil recovery to the decontamination of radioactive nuclear reactor materials. Adhesives, Sealants, Agrochemicals, Fertilizers Construction, Fine Chemicals Inks, Paints, Coatings, Metal Surface Treatment Oil Drilling Ore Mining and Refining Paper, Plastics, Polymers Textile, Leather Main Functions of Trisodium citrate: pH regulator Chelating agent Buffering agent Flavour enhancer Stabiliser Emulsifying agent Properties of Trisodium citrate: Trisodium citrate is in the form of a white, odorless powder with a slightly salty taste. Trisodium citrate occurs as a hydrate in combination with water. Trisodium citrate is characterized by the fact that Trisodium citrate is hygroscopic, so Trisodium citrate easily absorbs and combines with water. Therefore, Trisodium citrate should be stored under such conditions that Trisodium citrate is protected from moisture. Although Trisodium citrate is a salt of an acid, Trisodium citrate has an alkaline pH. Typical Properties: Dihydrate White Granular crystals or crystalline powder Typical, practically odourless Pleasantly salty Freely soluble in water Practically insoluble in ethanol (96 %) Non-toxic Low reactive Chemically and microbiologically stable Fully biodegradable Action Mechanism of Trisodium citrate: Trisodium citrate chelates free calcium ions preventing them from forming a complex with tissue factor and coagulation factor VIIa to promote the activation of coagulation factor X. This inhibits the extrinsic initiation of the coagulation cascade. Trisodium citrate may also exert an anticoagulant effect via a so far unknown mechanism as restoration of calcium concentration does not fully reverse the effect of citrate. Trisodium citrate is a weak base and so reacts with hydrochloric acid in the stomach to raise the pH. Trisodium citrate Trisodium citrate further metabolized to bicarbonate which then acts as a systemic alkalizing agent, raising the pH of the blood and urine. Trisodium citrate also acts as a diuretic and increases the urinary excretion of calcium. Pharmacology and Biochemistry of Trisodium citrate: MeSH Pharmacological Classification: Buffers: A chemical system that functions to control the levels of specific ions in solution. When the level of hydrogen ion in solution is controlled the system is called a pH buffer. Food Preservatives: Substances capable of inhibiting, retarding or arresting the process of fermentation, acidification or other deterioration of foods. Anticoagulants: Agents that prevent BLOOD CLOTTING. Manufacturing Method of Trisodium citrate: Prepare the Trisodium citrate buffer by mixing the Trisodium citrate, hydrochloric acid, and ultrapure water together in a 2L beaker or conical flask. Use a magnetic stirrer to ensure that all reagents are properly dissolved. Adjust to pH 6.01 with the 0.5% (w/v) sodium hydroxide and 0.5% (v/v) hydrochloric acid solutions. Add this solution to the pressure cooker. Place the pressure cooker on the hotplate and turn Trisodium citrate on to full power. Do not secure the lid of the pressure cooker at this point; simply rest Trisodium citrate on top. While waiting for the pressure cooker to come to the boil, dewax and rehydrate the paraffin sections by placing them in three changes of xylene for 3 min each, followed by three changes of IMS or methanol for 3 min each, followed by cold running tap water. Keep them in the tap water until the pressure cooker comes to the boil. Once the pressure cooker is boiling, transfer the slides from the tap water to the pressure cooker. Take care with the hot solution and steam—use forceps and gloves. Secure the pressure cooker lid following the manufacturer’s instructions. Once the cooker has reached full pressure (see manufacturer’s instructions), time for 3 min. When 3 min has elapsed, turn off the hotplate and place the pressure cooker in an empty sink. Activate the pressure release valve (see the manufacturer’s instructions) and run cold water over the cooker. Once depressurized, open the lid and run cold water into the cooker for 10 min. Take care with the hot solution and steam. Continue with an appropriate immunochemical staining protocol. Handling and storage of Trisodium citrate: Handling Ensure adequate ventilation. Avoid contact with skin, eyes or clothing. Avoid ingestionandinhalation. Avoid dust formation. Storage Keep containers tightly closed in a dry, cool and well-ventilated place. Stability and reactivity of Trisodium citrate: Reactive: Hazard None known, based on information available. Stability: Stable under normal conditions. Conditions to Avoid Incompatible products. Excess heat. Avoid dust formation. Incompatible Materials: Strong oxidizing agents, Strong reducing agents, Acids, Bases Hazardous Decomposition Products: Carbon monoxide (CO), Carbon dioxide (CO2), Sodium oxides Hazardous Polymerization: Hazardous polymerization does not occur. Hazardous Reactions None under normal processing. First-aid measures of Trisodium citrate: Eye Contact: Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Get medical attention if symptoms occur. Skin Contact: Wash off immediately with plenty of water for at least 15 minutes. If skin irritation persists, call a physician. Inhalation: Remove to fresh air. Get medical attention immediately if symptoms occur. If not breathing, give artificial respiration. Ingestion: Do NOT induce vomiting. Get medical attention immediately if symptoms occur. Most important symptoms and effects: No information available. Notes to Physician: Treat symptomatically Fire-fighting measures of Trisodium citrate: Suitable Extinguishing Media: Water spray, carbon dioxide (CO2), dry chemical, alcohol-resistant foam. Autoignition Temperature: 500 °C / 932 °F Accidental release measures of Trisodium citrate: Personal Precautions Ensure adequate ventilation. Avoid dust formation. Avoid contact with skin andeyes. Usepersonal protective equipment as required. Environmental Precautions No special environmental precautions required. Methods for Containment and Clean Up: Sweep up and shovel into suitable containers for disposal. Avoid dust formation. Identifiers of Trisodium citrate: CAS Number: 68-04-2 6132-04-3 (dihydrate) 6858-44-2 (pentahydrate) ChEMBL: ChEMBL1355 ChemSpider: 5989 ECHA InfoCard: 100.000.614 E number: E331iii (antioxidants, ...) PubChem CID: 6224 RTECS number: GE8300000 UNII: RS7A450LGA B22547B95K (dihydrate) CompTox Dashboard (EPA): DTXSID2026363 InChI: InChI=1S/C6H8O7.3Na/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3*+1/p-3 Key: HRXKRNGNAMMEHJ-UHFFFAOYSA-K InChI=1/C6H8O7.3Na/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3*+1/p-3 Key: HRXKRNGNAMMEHJ-DFZHHIFOAL SMILES: C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[Na+].[Na+].[Na+] CAS number: 6132-04-3 EC number: 200-675-3 Grade: Ph Eur,BP,JP,USP,E 331 Hill Formula: C₆H₅Na₃O₇ * 2 H₂O Molar Mass: 294.10 g/mol HS Code: 2918 15 00 Product Code: NA2043 CAS Number: 6132-04-3 Assay (purity): USP Purity method: by titration Molecular weight: 294.10 Form: solid Appearance: white powder Melting point: 300C Boiling point: 309.6C Titration: 99.0-101.0% Titration type: with HCLO4 Molecular formula: Na3C6H5O7 · 2H2O Linear formula: HOC(COONa)(CH2COONa)2 · 2H2O Properties of Trisodium citrate: Chemical formula: Na3C6H5O7 Molar mass: 258.06 g/mol (anhydrous), 294.10 g/mol (dihydrate) Appearance: White crystalline powder Density: 1.7 g/cm3 Melting point: > 300 °C (572 °F; 573 K) (hydrates lose water ca. 150 °C)
Boiling point: Decomposes
Solubility in water: Pentahydrate form: 92 g/100 g H2O (25 °C)
Melting Point: 300°C (anhydrous substance)
pH value: 7.5 – 9.0 (50 g/l, H₂O, 25°C)
Bulk density: 600 kg/m3
Solubility: 720 g/l
Molecular Weight: 294.10 g/mol
Hydrogen Bond Donor Count: 3
Hydrogen Bond Acceptor Count: 9
Rotatable Bond Count: 2
Exact Mass: 293.99396471 g/mol
Monoisotopic Mass: 293.99396471 g/mol
Topological Polar Surface Area: 143Ų
Heavy Atom Count: 18
Complexity: 211
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 6
Compound Is Canonicalized: Yes
Specifications of Trisodium citrate:
Assay (Perchloric acid titration, calc. on anhydrous substance (Ph Eur)): 99.0 – 101.0 %
Assay (Perchloric acid titration, previously dried substance) (JP/USP): 99.0 – 100.5 %
Identity (Na): passes test
Identity (Citrate): passes test
Identity (reaction upon ignition): passes test
Appearance: white to almost white crystals
Appearance of solution (100 g/l, CO₂-free water): clear and colorless
Acidity or alkalinity: passes test
pH (50 g/l CO₂-free water): 7.5 – 8.5
Chloride (Cl): ≤ 50 ppm
Sulfate (SO₄): ≤ 150 ppm
Heavy metals (as Pb): ≤ 5 ppm
Al (Aluminium): ≤ 5 ppm
As (Arsenic): ≤ 1 ppm
Hg (Mercury): ≤ 1 ppm
Pb (Lead): ≤ 1 ppm
Oxalate (as C₂H₂O₄): ≤ 100 ppm
Tartrate (C₄H₄O₆): passes test
Residual solvents (ICH (Q3C)): excluded by manufacturing process
Readily carbonisable substance: passes test
Water (according to Karl Fischer): 11.0 – 13.0 %
Loss on drying (180 °C, 18 h): 10.0 – 13.0 %
Related compounds of Trisodium citrate:
Monosodium citrate
Disodium citrate
Calcium citrate
Citric acid
Names of Trisodium citrate:
IUPAC names:
1,2,3-propanetricarboylic acid, 2-hydroxy- trisodium salt, dihydrate
2-Hydroxy-1,2,3-propanetricarboxylic acid, trisodium sal
2-Hydroxy-1,2,3-propanetrioïc acid, trisodium salt
Ascorbato di sodio trisodico anidro E331
Citric acid trisodium salt, Sodium citrate tribasic, Sodium citrate
sodium 2-hydroxypropane-1,2,3-tricarboxylate
SODIUM CITRATE
Sodium citrate
sodium citrate
Sodium citrate
sodium citrate dihydrate
Sodium Citrate dihydrate
Sodium Citrate- OR 10
Tri sodium citrate
Tri Sodium Citrate
Trinatiumcitrat dihydrat
Trinatrium-2-hydroxypropan-1,2,3-tricarboxylat
Trisodium 2-hydroxypropane-1,2,3-
Trisodium 2-hydroxypropane-1,2,3- tricarboxylate
Trisodium 2-hydroxypropane-1,2,3-tricarboxylate
trisodium 2-hydroxypropane-1,2,3-tricarboxylate
trisodium 2-hydroxypropane-1,2,3-tricarboxylate dihydrate
Trisodium 2-hydroxypropane-1,2,3-tricarboxylateTrisodium citrate
Trisodium 3-hydroxy-3- carboxylate-1,5-pentanedicaroxylate
TRISODIUM CITRATE
Trisodium Citrate
Trisodium citrate
trisodium citrate
Trisodium Citrate
Trisodium citrate
trisodium citrate
trisodium citrate (dihydrate)
trisodium citrate 2-hidrate
Trisodium Citrate Dihydrate
trisodium citrate dihydrate
Trisodium citrate, Trisodium 2-hydroxypropane-1,2,3-tricarboxylate
Trisodium citrate; Trisodium 2-hydroxypropane-1,2,3-tricarboxylate
trisodium2-hydroxypropane-1,2,3-tricarboxylate
trisodium;2-hydroxypropane-1,2,3-tricarboxylate
trisodium;2-hydroxypropane-1,2,3-tricarboxylate;dihydrate
Preferred IUPAC name:
Trisodium 2-hydroxypropane-1,2,3-tricarboxylate
Regulatory process names:
Sodium citrate anhydrous
Trisodium citrate
trisodium citrate
Trade names:
Citrate de trisodium, dihydrate
Citrato de trisodio, dihidrato
Sodio citrato
SODIUM CITRATE
Sodium Citrate
SODIUM CITRATE DIHYDRATE
Tri-Sodium Citrate Dihydrate
Trinatriumcitraatdihydraat
Trinatriumcitrat-Dihydrat
Trisodio citrato diidrato
Trisodium citrate
trisodium citrate
TRISODIUM CITRATE DIHYDRATE
Trisodium citrate dihydrate
TRISODIUM CITRATR
Other names:
Sodium citrate
Trisodium citrate
Citrosodine
Citric acid, trisodium salt
E331
Other identifiers:
1000844-65-4
1648840-06-5
183748-56-3
2095548-08-4
6132-04-3
68-04-2
8055-55-8
856354-90-0